《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (05): 340-342.

• 基础研究 • 上一篇    下一篇

维吾尔医沙疗对兔膝骨关节炎细胞因子的影响

卫荣1; 迪丽娜·马合木提2; 卡哈尔·库尔班3; 亚力孔·卡地尔3   

  1. 1.新疆医科大学第一附属医院 新疆乌鲁木齐市 830054;2.新疆大学 新疆乌鲁木齐市 830008;3.新疆吐鲁番地区维吾尔医院 新疆吐鲁番市 838000
  • 收稿日期:2005-03-29 出版日期:2005-05-25 发布日期:2005-05-25

Effects of the sand therapy of Uyghur Traditional Medicine on cytokines of the experimental knee osteoarthritis in rabbit

WEI Rong,Dilina Mahemuti, Kahaer Kuerban, et al   

  1. First Affiliated Hospital, Xinjiang Medical University, Urumuqi 830054, Xinjiang,China
  • Received:2005-03-29 Published:2005-05-25 Online:2005-05-25

PDF (PC)

摘要： 目的探讨维吾尔医沙疗对骨关节炎模型动物关节液、血液中白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、一氧化氮(NO)的影响。方法新西兰兔右膝关节腔内注射木瓜蛋白酶,再随机分成3 组。从造模第15 天开始,Ⅰ组予埋沙治疗,Ⅱ组予芬必得灌胃,Ⅲ组不作任何处理。第30天留取血清及关节液标本检测IL-1β、TNF-α、NO水平。并取滑膜及软骨组织作组织病理学观察。结果Ⅰ组的软骨及滑膜病变程度较Ⅱ、Ⅲ组减轻;Ⅰ、Ⅱ组关节液中的IL-1β、TNF-α的水平及血清中NO水平较Ⅲ组明显降低。结论维吾尔医沙疗通过抑制关节液中细胞因子升高而发挥其对骨关节炎的防治作用。

关键词: 维吾尔医学, 沙疗, 骨关节炎, 细胞因子, 兔

Abstract: ObjectiveTo study the effects of the sand therapy of Uyghur Traditional Medicine on cytokines,such as interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α), nitric oxide(NO) of the rabbit experimental knee osteoarthritis. Methods27 rabbits were injected papain into the joint space of right knee, and divided randomly into three groups. 15 d after the articular injection, the rabbits of group Ⅰ were treated with the sand therapy, the rabbits of group Ⅱ were treated with fenbid, and Ⅲ group accepted no treatment for the blank control.15 d after treatment, the serum and the douche fluid of the diseased joints were obtained to measure the level of IL-1β,TNF-α and NO. The synovium and the cartilage was observed histopathologically.ResultsCompare with group Ⅱ and Ⅲ, the pathological changes of cartilage and synovitis in group Ⅰ lighten significantly. Compare with groupⅢ,the level of IL-1β, TNF-α in articular douche fluid and NO in serum of group Ⅰ and Ⅱ decreased significantly. ConclusionThe sand therapy can decrease the level of cytokines in the focus joints, which may play a role of treatment in osteoarthritis.

Key words: Uyghur Traditional Medicine, sand therapy, osteoarthritis, cytokines