《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (04): 297-298.

• 临床研究 • 上一篇    下一篇

临床产超广谱β-内酰胺酶菌株的耐药性分析

李晨1,5; 周树清2; 高军3; 陈惠4; 马岳珠4   

  1. 1.北京博爱医院院感科 北京市 100068;2.北京博爱医院医务处 北京市 100068;3.北京博爱医院药剂科 北京市 100068;4.北京博爱医院检验科 北京市 100068;5.北京市首都医科大学2002级在职研究生 北京市 100068
  • 收稿日期:2005-03-04 出版日期:2005-04-25 发布日期:2005-04-25

Antimicrobial resistance of bacteria strains producing extend spectrum β-lactamase in clinic

LI Chen, ZHOUShu-qing, GAO Jun, et al   

  1. The Department of Nosocomial Infection, The Beijing Charity Hospital, Beijing 100068, China
  • Received:2005-03-04 Published:2005-04-25 Online:2005-04-25

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摘要： 目的探讨临床产超广谱β-内酰胺酶(ESBLs)菌株的耐药谱特点及其耐药变迁趋势。方法采用MIC方法对2001年4月～2004年3月我院临床标本中分离出的非重复大肠埃希菌和肺炎克雷伯菌进行产ESBLs株初筛,用双纸片扩散法做表型确证试验。结果临床产ESBLs菌株分离率呈逐年上升趋势,其耐药率和最小抑菌浓度几何均数Gm均高于ESBLs阴性菌株。结论应加强对产ESBLs菌株的检测,为合理使用抗生素提供依据。

关键词: 超广谱β-内酰胺酶, 最小抑菌浓度, 医院内感染

Abstract: ObjectiveTo investigate the resistance character and trend of bacteria strains producing extend spectrum β-lactamase (ESBLs) in clinic.MethodsThe ESBLs-producting K. pneumoniae and E.coli producing ESBLs isolated from Apr 2001 to Mar 2004 in our hospital were screened and confirmed according to NCCLs method.ResultsK. pneumoniae and E.coli with the ESBLs phenotype were increased in recent 3 years with the resistance rate and Gm(MIC) also higher than that not producing ESBLs.ConclusionThe dection of bacteria strains producing ESBLs will be enhanced in order to provide reasonable treatment information.

Key words: extended-spectrum β-lactamase (ESBLs), minimum inhibitory concentration (MIC), nosocomial infection