《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (08): 701-702.

• 专题 •    下一篇

不同剂量甲泼尼龙与神经节苷脂联合治疗实验性脊髓损伤

罗玉玉1; 李晓东2; 张文成1   

  1. 1.中国人民武装警察部队医学院生理学与病理生理学教研室,天津市 300162;2.天津市第三中心医院骨科,天津市 300170
  • 收稿日期:2008-03-28 出版日期:2008-08-01 发布日期:2008-08-01

Effect of Different Doses Methylprednisolone Combined with Monosialotetrahexosyl Ganglioside on Experimental Spinal Cord Injury

LUO Yu-yu, LI Xiao-dong, ZHANG Wen-cheng   

  1. The Department of Physiology and Pathophysiology, MedicalCollege of Chinese People's Armed Police Force, Tianjin 300162, China
  • Received:2008-03-28 Published:2008-08-01 Online:2008-08-01

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摘要： 目的比较两种不同剂量的甲泼尼龙(MP)与单唾液酸神经节苷脂(GM-1)联合应用治疗实验性脊髓损伤的效果。方法36只大鼠随机分为3组,复制挤压性脊髓损伤动物模型,分别应用大剂量MP和两种不同剂量MP与GM-1联合治疗,测定损伤即刻、术后第7天、第14天各组动物的脊髓运动诱发电位(MEP)变化,并进行运动功能BBB评分。结果各组动物损伤后MEP波峰潜伏时延长,波幅降低,BBB评分降低,术后第7天和第14天各组动物的MEP及BBB评分均有不同程度恢复,联合用药组较单独应用大剂量MP组效果明显,其中又以小剂量MP+GM-1组恢复最明显。结论小剂量MP和GM-1联合应用治疗实验性脊髓损伤的效果优于大剂量MP单独应用或中剂量MP联合GM-1。

关键词: 甲泼尼龙, 神经节苷脂, 脊髓损伤

Abstract: Objective To compare the treatment effect of different doses methylprednisolone(MP)combined with monosialotetrahexosyl ganglioside(GM-1)on experimental spinal cord injury.Methods Based on the duplication of compressed spinal cord animal model,36 rats were divided into three groups randomly:the first group with high dose of MP,the second with moderate dose of MP and GM-1,the third with low dose of MP and GM-1.The motor evoked potential(MEP)and the grades of BBB were detected on the 7th day and 14th day after injury.Results The peak latencies and the amplitudes of MEP and the BBB grades changed significantly after injury in the three groups.After treatment by different administration,the recovery of the two combined groups was more obvious than that of the high dose MP group,and the effect with the low dose of MP and GM-1 group was most significant.Conclusion The treatment effect of low dose MP combined with GM-1 is better than the other two therapies on experimental spinal cord injury.

Key words: methylprednisolone, monosialotetrahexosyl ganglioside(GM-1), spinal cord injury