《中国康复理论与实践》

《中国康复理论与实践》 ›› 2008, Vol. 14 ›› Issue (08): 736-738.

• 综述综述 • 上一篇    下一篇

多发性硬化免疫治疗新方向

林丽莉; 李林   

  1. 首都医科大学宣武医院药物研究室; 神经变性病教育部重点实验室,北京市 100053
  • 收稿日期:2008-03-10 出版日期:2008-08-01 发布日期:2008-08-01

New Trends in Immunotherapy of Multiple Sclerosis (review)

LIN Li-li, LI Lin   

  1. The Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China
  • Received:2008-03-10 Published:2008-08-01 Online:2008-08-01

PDF (PC)

被引次数

3

摘要： 多发性硬化(MS)是一种与自身免疫相关的中枢神经系统病变,因对其发病机制缺少了解,过去主要应用免疫抑制进行治疗。笔者对广谱免疫抑制治疗MS的利弊进行分析,并将近几年有关细胞因子、趋化因子和黏附因子对MS作用的研究进展及为此提供的免疫治疗新方向进行综述。

关键词: 多发性硬化, 免疫调节, 趋化因子, 综述

Abstract: Multiple sclerosis(MS)is a kind of autoimmune-associated central nervous system disease.Because of the limited information about the mechanism,MS has been treated by immunosuppressive agents.In this review,the authors will compare the benefits with facing risks of conventional immunosuppressive treatments.Current and future immunosuppressive and immunomodulating therapeutic approaches at the level of cytokine,chemokine and adhesion factors are also discussed in this review.

Key words: multiple sclerosis, immunomodulation, chemokine, review