《中国康复理论与实践》

《中国康复理论与实践》 ›› 2005, Vol. 11 ›› Issue (01): 21-22.

• 基础研究 • 上一篇    下一篇

脑疏宁对大鼠颅脑创伤后神经功能影响的实验研究

崔向宁1; 尹岭2; 王玉来1   

  1. 1.北京中医药大学东方医院 北京市 100078;2.解放军总医院神经信息中心 北京市 100853
  • 收稿日期:2004-10-13 出版日期:2005-01-25 发布日期:2005-01-25

Effects of Naoshuning on neurological outcome following traumatic brain injury in rats

CUI Xiang-ning, YIN Ling, WANG Yu-lai   

  1. Dongfang Hospital,Beijing University of Tranditional Chinese Medicine,Beijing 100078, China
  • Received:2004-10-13 Published:2005-01-25 Online:2005-01-25

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被引次数

13

摘要： 目的评价中药脑疏宁对创伤性脑损伤 (TBI)后神经功能的保护作用。方法按Feeney自由落体撞击法造成TBI模型,通过木条行走实验评价伤后大鼠的神经功能恢复情况,并在伤后不同时间点观察脑组织含水量及病理改变。结果伤后1周内大鼠完成木条行走作业的能力明显受损。经脑疏宁治疗后,TBI大鼠神经功能明显改善,脑组织含水量及病理改变减轻。结论中药脑疏宁可以促进颅脑损伤后神经功能的恢复,可能与早期减轻脑水肿、保护脑组织有关。

关键词: 创伤性脑损伤, 脑疏宁, 神经功能, 大鼠

Abstract: ObjectiveTo observe the protective effects of Chinese medicine Naoshuning on neurological deficits following traumatic brain injury (TBI) in rats.MethodsCerebral contusion was produced by dropping weight,the beam-walking task was employed to observe neurological functional changes,water content in the brain tissue and neuropathological changes were also evaluated.ResultsWithin one week the ability to process in beam-walking task was significantly lessened,the outcome of beam-walking task of Naoshuning group was significantly better than that of the model group.Water content in the brain tissue and neuropathological changes were also alleviated in Naoshuning group compared with that in model group.ConclusionEarly alleviating brain edema,protecting brain tissue may be one of the mechanism of Chinese medicine to ameliorate the behavior deficits following TBI in rats.

Key words: traumatic brain injury, Naoshuning, neurological function, rats