《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (11): 641-643.

• 专题 •    下一篇

空间诱变肿瘤细胞的初步实验

唐劲天; 向青; 徐梅; 陈志华; 李红艳; 房青; 刘轩; 徐波; 耿传营; 赵天德; 陈惟昌   

  1. 中日友好医院临床医学研究所生化分子生物研究室 北京市 100029
  • 收稿日期:2004-10-13 出版日期:2004-11-25 发布日期:2004-11-25

Primary investigation of space mutated tumor cells

TANG Jin-tian,XIANG Qing,XU Mei,et al   

  1. Department of Biochemistry and Molecule Biology,Institute of Clinical Medical Science,China-Japan Friendship Hospital, Beijing 100029,China
  • Received:2004-10-13 Published:2004-11-25 Online:2004-11-25

PDF (PC)

被引次数

13

摘要： 目的利用空间环境诱变细胞,探索肿瘤免疫治疗新途径。方法将肿瘤细胞无源搭载于神舟4号飞船与第18颗返回式卫星,分别经7d和18d的空间飞行,回收后对一些生理特征进行了初步研究。结果搭载于神舟4号飞船的肿瘤细胞经单克隆化后,获得诱变细胞2382株,第18颗返回式卫星搭载4株肿瘤细胞,但仅存活1株B16细胞。与地面对照组相比,空间诱变肿瘤细胞生长速度减慢,细胞因子分泌改变。结论空间环境可影响肿瘤细胞的生理特征,而且细胞存活的数量有与搭载时间长短呈负相关的趋势。

关键词: 空间环境, 肿瘤细胞, 生理特征

Abstract: ObjectiveTo search for a new method of anti-tumor immunity,using mutated tumor cells by spaceflight.MethodsTumor cells were carried in the Shenzhou 4 and the recoverable satellite No.18.After 7 days and 18 days spaceflight respectively,the effects of spaceflight were investigated primarily.Results2382 and 1 strains of mutated tumor cells from the airship No.4 and the recoverable satellite No.18 had been obtained respectively. Comparing with the control group, the growth rate of mutated cells decreased, moreover, the secretion of cytokines also changed.ConclusionSpaceflight may affect physiological characteristics of tumor cells, and that, there was a negative correlation between the ratio of surviving cells and carrying time.

Key words: space environments, tumor cells, physiological characteristics