《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (10): 608-609.

• 临床研究 • 上一篇    下一篇

托特罗定治疗脊髓损伤后逼尿肌反射亢进疗效观察

孙知寒 ; 关骅 ; 石晶   

  1. 1.北京博爱医院 北京市 100068;2.首都医科大学康复医学院 北京市 100068
  • 收稿日期:2003-10-27 出版日期:2004-10-25 发布日期:2004-10-25

Clinical effect of tolterodine on detrusor hyperreflexia of patients with spinal cord injury

SUNZhi-han, GUAN Hua, SHI Jing   

  1. Beijing Charity Hospital, Beijing 100068, China
  • Received:2003-10-27 Published:2004-10-25 Online:2004-10-25

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摘要： 目的评价托特罗定治疗脊髓损伤后逼尿肌反射亢进的疗效及安全性。方法20例脊髓损伤后逼尿肌反射亢进患者口服托特罗定每日2次,每次2mg,共治疗12周。通过治疗前后尿动力学和排尿日记的数据分析,评价托特罗定的疗效与安全性。结果治疗12周后,患者平均每次排尿量从(113.95±26.59)ml增加到(176.58±37.86)ml(P<0.01);平均功能性膀胱容量从(217.63±33.76)ml增加到(231.32±39.72)ml(P<0.05);排尿间隔时间从(126.58±21.41)min延长到(151.05±19.83)min(P<0.01);第一次收缩时膀胱容量从(62.62±36.37)ml增加到(126.75±34.64)ml(P<0.01);最大逼尿肌收缩压力从(74.81± 28.60)cmH2O降至(61.90±16.22)cmH2O(P<0.05);最大收缩波幅从(47.24±30.42)cmH2O降至(39.36±25.28)cmH2O(P<0.05)。结论托特罗定治疗脊髓损伤后逼尿肌反射亢进安全有效,且依从性良好,不良反应较少。

关键词: 托特罗定, 脊髓损伤, 逼尿肌反射亢进

Abstract: ObjectiveTo evaluate th effect and safety of tolterodine on detrusor hyperreflexia of patients with spinal cord injury.Methods20 cases of spinal cord injury patients with detrusor hyperreflexia were treated with tolterodine (2mg, twice daily), and the data of urodynamics and voiding diary before and after treatment were evaluated.ResultsAfter 12 weeks of treatment, it showed a significant increase from baseline in mean voiding volume (P<0.01), functional bladder volume (P<0.05) and interval of voiding (P<0.01). The bladder volume at first contraction significantly increased from (62.62±36.37)ml to (126.75±34.64)ml (P<0.01), the maximal pressure of detrusor contraction significantly decreased from (74.81±28.60) cm H2O to (61.90±16.22) cm H2O (P<0.05), the maximal amplitude of wave significantly decreased from (47.24±30.42) cm H2O to (39.36±25.28) cm H2O.ConclusionTolterodine is effective and safety to detrusor hyperreflexia of patients with spinal cord injury, and has a better therapeutic compliance and less adverse reactions.

Key words: tolterodine, spinal cord injury, detrusor hyperreflexia