《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (10): 606-607.

• 临床研究 • 上一篇    下一篇

托特罗定治疗脊髓损伤后逼尿肌反射亢进39例

刘根林1,2; 郑樱1,2; 郝春霞1,2; 周红俊1,2; 黄彦红3   

  1. 1.首都医科大学康复医学院 北京市 100068;2.北京博爱医院脊髓损伤康复科 北京市 100068;3.北京积水潭医院 北京市 100035
  • 收稿日期:2004-08-11 出版日期:2004-10-25 发布日期:2004-10-25

Effect of tolterodine on 39 spinal cord injured patients with detrusor hyperreflexia

LIU Gen-lin, ZHENG Ying, HAO Chun-xia, et al   

  1. Department of Spinal Cord Injury Rehabilitation of Beijing Charity Hospital, Faculty of Rehabilitation of the Capital University of Medical Sciences, Beijing 100068, China
  • Received:2004-08-11 Published:2004-10-25 Online:2004-10-25

PDF (PC)

被引次数

5

摘要： 目的观察托特罗定治疗脊髓损伤后逼尿肌反射亢进的有效性和安全性。方法 39例脊髓损伤患者连续服药2周以上,平均(8.31±6.47)个月,有效剂量为1-12mg/日,平均(5.82±3.13)mg/日;其中12例患者长期服药(剂量1—8mg/日),并随访1年。结果 39例患者有效37例(94.87%),平均膀胱容量扩大(74.36±35.32)ml(P<0.001),24h排尿次数减少(3 .85±2.38)次(P<0.001),每次排尿量增加(49.74±41.20)ml(P<0.001),残余尿量增加(64.62±41.98)ml(P<0.001);2例肾积水患者积水消失。药物副作用 :口干8例(20.51%)、心慌1例、尿潴留1例,服药超过1年的患者心电图及肝肾功能无异常。结论托特罗定治疗脊髓损伤后逼尿肌反射亢进效果明确,安全可靠。

关键词: 托特罗定, 脊髓损伤, 逼尿肌反射亢进

Abstract: ObjectiveTo observe the efficacy and tolerability of tolterodine on spinal cord injured (SCI) patients with detrusor hyperreflexia.Methods39 cases were treated with tolterodine administration for at least two weeks (8.31±6.47 months in average), the range of drug dosage was 1 mg to 12 mg per day, 5.82±3.13 mg in average. Twelve of them have taken the drug (1-8 mg per day) for one year.ResultsAfter two weeks of treatment, 37 cases (94.87%) had a good effect, and the bladder volume increased 74.36±35.32 ml (P<0.001), the mean frequency of micturition decreased 3.85±2.38 times (P<0.001), urine of each micturition increased 49.74±41.20 ml (P<0.001), the residual urine increased 64.62±41.98 ml(P<0.001).Additionally, hydronephrosis of two cases was remitted. The adverse events: 8 cases of thirsty, 1 case of tachycardia and 1 case of urine retention.ConclusionTolterodine has a good effect and limited side effects on SCI patients with detrusor hyperreflexia.

Key words: tolterodine, spinal cord injury (SCI), detrusor hyperreflexia