《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (10): 588-589.

• 基础研究 • 上一篇    下一篇

双龙丸对实验性心肌梗死形态学和血流动力学的影响

杨祖福1; 胡婉英2; 薛金贵2   

  1. 1.北京博爱医院内科 北京市 100068;2.上海中医药大学曙光医院心内科 上海市 200032
  • 收稿日期:2004-09-02 出版日期:2004-10-25 发布日期:2004-10-25

Effect of Shuanglong pill on morphology and haemodynamics in experimental myocardial infarction rats

YANG Zu-fu, HU Wan-ying, XUE Jin-gui   

  1. Department of Internal Medicine, Beijing Charity Hospital, Beijing 100068, China
  • Received:2004-09-02 Published:2004-10-25 Online:2004-10-25

PDF (PC)

摘要： 目的探讨活血通络类中药双龙丸对心肌梗死后心脏血流动力学和心肌梗死面积的影响。方法参照Drexler法结扎冠脉左前降支,制成急性心肌梗死(AMI)模型。66只大鼠分为双龙丸大剂量组(18只)、双龙丸小剂量组(19只)、正常对照组(10只)和心肌梗死对照组(19只)。各组半数治疗2周,半数治疗至4周,治疗结束时分别行股动脉和颈总动脉插管,应用8导生理记录仪检测心脏血流动力学参数,Masson’s染色测定心肌梗死面积。结果治疗2周和4周,双龙丸大、小剂量组较同期心肌梗死对照组的左室最大收缩速率增高(P<0.05或P<0.01),且大剂量2周组较心肌梗死对照组的左室最大舒张速率亦增高(P<0.05);大剂量组在2周和4周时均较心肌梗死对照组的梗死面积减小 (P<0.05)。结论双龙丸能提高实验性心肌梗死大鼠的左室最大收缩速率,大剂量应用还可改善心肌梗死早期左室舒张功能,限制心肌梗死范围的扩展。

关键词: 双龙丸, 实验性心肌梗死, 形态学, 血流动力学, 梗死面积

Abstract: ObjectiveTo explore the effect of Shuanglong pill which can vivid blood and relax thread pulse on cardial morphology and haemodynamics in experimental myocardial infarction (MI) rats.Methods66 rats ligated left coronary artery were randomly divided into large dose group of Shuanglong pill (LDG), small dose group of Shuanglong pill (SDG), the normal control (NC) and the control group of MI. Half in each group received 2 week treatment and the other received 4 week treatment, and were spiled in femoral and common carotid artery respectively. Parameters of cardiac haemodynamics were monitored by eight lead physiological recorder. ResultsLeft ventricular systolic maximum velocity in LDG, SDG and DC was more significantly elevated than in MI, after 2 weeks and 4 weeks of treatment, but it was lower than NC. There were no significant differences among LDG, SDG and DC. Ventricular systolic maximum velocity in LDG was more significantly elevated than in MI after 2 week treatment.ConclusionTreating MI with Shuanglong pill can improve left ventricular systolic maximum velocity, and diastolic phase function of left ventricular also elevate during the acute stage of MI by using large dose.

Key words: Shuanglong pill, experimental myocardial infarction, morphology, hemodynamics, infarction area