《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (09): 529-531.

• 基础研究 • 上一篇    下一篇

高压氧对血管性痴呆大鼠海马胆碱能神经元的影响及行为学疗效

叶建新;姚丽青   

  1. 南京军区福州总医院神经内科 福建福州市 350025
  • 收稿日期:2004-03-22 出版日期:2004-09-25 发布日期:2004-09-25

Effect of hyperbaric oxygen therapy on the cholinergic neurons of hippocampus and praxiology of vascular dementia rats

YE Jian-xin,YAO Li-qing   

  1. Department of Neurology, Department of Pathology. Fuzhou Military General Hospital of Nanjing Army Area,Fuzhou 350025, Fujian, China
  • Received:2004-03-22 Published:2004-09-25 Online:2004-09-25

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摘要： 目的研究高压氧(HBO)治疗对血管性痴呆大鼠海马胆碱能神经元及行为的影响。方法制作血管性痴呆大鼠模型,随机分成对照组及治疗组,HBO治疗30d后,用Morris水迷宫检测大鼠空间记忆能力,免疫组织化学染色检测海马CA1区胆碱能神经元数目的变化。结果治疗组大鼠空间记忆能力明显提高,海马CA1区胆碱能数目较对照组明显增加。结论高压氧对血管性痴呆大鼠有明显治疗作用。

关键词: 高压氧, 血管性痴呆, 胆碱能神经元, Morris水迷宫, 大鼠

Abstract: ObjectiveTo study the effect of hyperbaric oxygen therapy on the cholinergic neurons of hippocampus and praxiology of vascular dementia rats.MethodsThe vascular dementia models were made and divided into control and therapy group. After 30 days of HBO therapy, abilities of learning and memory of rats were tested by using the Morris water maze. Immunochemistry staining was used to observe the number of cholinergic neurons of CA1 subfield of hippocampus. ResultsAbilities of learning and memory of rats and the number of the neurons positive to ChAT like immunoreaction in the CA1 subfield of the hippocampus significantly increased in therapy group.ConclusionHyperbaric oxygen therapy is effective on the vascular dementia model rats.

Key words: hyperbaric oxygen therapy, vascular dementia, cholinergic neurons, Morris water maze, rat