《中国康复理论与实践》

《中国康复理论与实践》 ›› 1997, Vol. 3 ›› Issue (04): 168-171.

• 理论与实践 • 上一篇    下一篇

截瘫患者气管插管应激反应的临床研究

迟肇丛1; 王强1; 蒋薇薇2   

  1. 1.中国康复研究中心麻醉科;2.中国康复研究中心基础所
  • 收稿日期:1996-06-21 出版日期:1997-12-25 发布日期:1997-12-25

Clinical Observation of the Stress Response of Patient with Paraplegia to Intratracheal Intubation

Chi Zhaocong,Wang Qiang,Jiang Weiwei   

  1. Chinese Journal of Rehabilitation Theory & Practice.-1997,3(4):168～171
  • Received:1996-06-21 Published:1997-12-25 Online:1997-12-25

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摘要： 20例胸腰段截瘫患者，随机分为两组。Ⅰ组静注硫酸喷妥纳、潘库溴铵及小剂量芬太尼诱导，诱导前舌下含化硝苯吡啶，肌松后插管。Ⅱ组仅静注硫喷妥钠与潘库溴铵。两组分别于诱导前后定时进行血流动力学及血浆儿茶酚胺含量的测定。结果显示Ⅰ组的各项血流动力学测定指标与血浆儿芬酚胺含量接近或低于诱导前基础值，而Ⅱ组插管后均明显上升，两组对比有显著性差异，说明胸腰段脊髓损伤患者气管插管时仍存在血压上升、心率增快及血浆儿茶酚胺增多的应激反应，小剂量芬太尼与硝苯吡啶可有效地减弱插管时的应激反应。

关键词: 气管内插管, 应激, 硝苯吡啶, 芬太尼

Abstract: 20 patients with paralysis at thoracic or lumbar level were randomly divided into twogroups. Patients in the lst group receive thiopental, pancuronium, fentanyl in small dose and nifedipine10mg before intubation.Patients in the 2nd group receive thiopental and pancuronium. Hemodynamic indices and serum catecholamine concentrations were measured at different time intervals pre and post-intubation.The results show that each variables of hemodynamic indices and serum concentration in the lst groupare approximate or lower than the values of pre--intubation,but each value of the 2nd group at post--intubation increase significantly.The study demonstrated that nifedipine and fentanyl in small dosage may effectively ameliorate thestress response during intubation.

Key words: endotracheal intubation, stress, nifedipine, fentanyl