《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (02): 149-151.

• 综述 • 上一篇    下一篇

大鼠大脑中动脉脑缺血模型的影响因素

江晓峰1,2;何玥3;胡雪艳2,4;张通2,4   

  1. 1. 首都医科大学公共卫生与家庭医学学院，北京市 100069;2. 首都医科大学康复医学院，北京市 100068;3. 首都医科大学基础医学院，北京市 100069;4. 中国康复研究中心北京博爱医院神经康复科，北京市 100068
  • 收稿日期:2008-07-21 出版日期:2009-02-01 发布日期:2009-02-01

Factors Affecting Cerebral Ischemia Model of Rat Established by Middle Cerebral Artery Occlusion (review)

JIANG Xiao-feng, HE Yue, HU Xue-yan, et al   

  1. Capital Medical University School of Public Health and Family Medicine, Beijing 100069, China
  • Received:2008-07-21 Published:2009-02-01 Online:2009-02-01

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摘要： 影响大鼠大脑中动脉闭塞脑缺血动物模型建立的因素有：大鼠品种、麻醉剂、手术部位和线栓等，其中线栓的选择是模型制作成功的关键，包括线栓的种类、长度、直径、硬度、放置方法，以及线栓端部的处理等。线栓制备等因素的改进大大提高了脑缺血动物模型的成功率。

关键词: 脑缺血, 大鼠, 动物模型, 综述

Abstract: The factors affecting cerebral ischemia model of rat established by middle cerebral artery occlusion include animal selection, drugs of anesthesia, surgical site, thread affect building, and etc. To find and manufacture an appropriate thread is the key to success. It includes the species, length, diameter, hardness, and placing method of the thread. The improvement of these factors greatly increases the successful rate in the establishment of focal cerebra ischemia model of rat caused by middle cerebral artery occlusion.

Key words: cerebral ischemia, rat, animal model, review