《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (02): 138-140.

• 基础研究 • 上一篇    下一篇

脑心通胶囊对大鼠脑缺血再灌注损伤的保护作用

陈军1a;鲁雅琴1a;吕海宏1b;陈江君1a;王颖1a;杨奎1a;刘宁1a   

  1. 1. 兰州大学第一医院，a.神经内科;b.内分泌科;甘肃兰州市 730000
  • 收稿日期:2008-07-30 修回日期:2008-10-15 出版日期:2009-02-01 发布日期:2009-02-01

Protective Effects of Naoxintong Capsule on Cerebral Ischemia-reperfusion Injury in Rats

CHEN Jun, LU Ya-qin, Lü Hai-hong, et al   

  1. The Department of Neurology, Lanzhou University First Hospital, Lanzhou 730000, Gansu, China
  • Received:2008-07-30 Revised:2008-10-15 Published:2009-02-01 Online:2009-02-01

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摘要： 目的 探讨脑心通胶囊对大鼠脑缺血再灌注损伤的保护作用。方法 45只SD大鼠随机分为5组：假手术组（5只）、缺血再灌注组（10只）、脑心通胶囊小剂量组（10只）、脑心通胶囊大剂量组（10只）、辅酶Q10组（10只）。采用双侧颈总动脉结扎法制作不完全性脑缺血再灌注模型，分别观察脑缺血30 min再灌注30 min及缺血30 min再灌注60 min脑组织含水量和ATP酶活性。结果 缺血再灌注组与假手术组比较，Na+-K+-ATP酶、Ca2+-ATP酶和 Mg2+-ATP酶活性降低，脑含水量增加，差异有非常显著性意义（P<0.01）；脑心通胶囊组与缺血再灌注组比较，Na+-K+-ATP酶、Ca2+-ATP酶和Mg2+-ATP酶活性增加，脑含水量降低，且差异有非常显著性意义（P<0.01）。结论 脑心通胶囊对脑缺血再灌注损伤有保护作用。

关键词: 脑心通胶囊, 再灌注损伤, 大鼠

Abstract: Objective To investigate the protective effects of Naoxintong capsule on cerebral ischemia-reperfusion injury in rats.Methods 45 SD rats were randomly divided into 5 groups: sham operation group (n=5), ischemia-reperfusion group (n=10), small dose of Naoxintong capsule group (n=10), large dose of Naoxintong capsule group (n=10), CoQ-10 group (n=10). The the cerebral ischemia-reperfusion model was established by occluding bilateral carotid arteries of animal. The moisture content and activity of ATPase in brain tissue of model rat were observed respectively at ischemia 30 min plus reperfusion 30 min and ischemia 30 min plus reperfusion 60 min.Results The activities of Na+-K+-ATPase, Ca2+-ATPase and Mg2+-ATPase decreased (P<0.01), contents of water in brain tissues increased (P<0.01) in the ischemia-reperfusion group, compared with the sham operation group. The activities of Na+-K+-ATPase, Ca2+-ATPase and Mg2+-ATPase increased (P<0.01), contents of water in brain tissues decreased (P<0.01) in the Naoxintong capsule group, compared with the ischemia-reperfusion group.Conclusion Naoxintong capsule can protect the brain tissue from ischemia-reperfusion injury.

Key words: Naoxintong capsule, reperfusion injury, rat