《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (02): 132-134.

• 基础研究 • 上一篇    下一篇

碱性成纤维细胞生长因子对血管性痴呆大鼠头颅磁共振波谱的影响

叶建新1,2;林航1,2;穆军山1,2;崔晓萍1,2;殷红兵1,2;林敏1,2;武雷1,2;翁婧1,2;林晓姝1,2   

  1. 1. 南京军区福州总医院神经内科，福建福州市 350025;2. 福建医科大学福总临床医学院，福建福州市 350025
  • 收稿日期:2008-08-26 出版日期:2009-02-01 发布日期:2009-02-01

Effect of Basic Fibroblast Growth Factor on Magnetic Resonance Spectroscopy of Vascular Dementia Rats

YE Jian-xin, LIN Hang, MU Jun-shan, et al   

  1. The Department of Neurology, Fuzhou General Hospital of Nanjing Army Area, Clinical Medical College of Fujian Medical University, Fuzhou 350025, Fujian, China
  • Received:2008-08-26 Published:2009-02-01 Online:2009-02-01

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摘要： 目的 观察碱性成纤维细胞生长因子（bFGF）对血管性痴呆（VD）大鼠头颅磁共振波谱的影响。方法 制作VD大鼠模型，随机取用VD模型大鼠12只，分为治疗组6只、痴呆组6只。另取6只大鼠为假手术组。治疗组大鼠皮下注射bFGF。5周后，以Morris水迷宫定位航行试验和空间探索试验检测大鼠的学习记忆能力，观察颞叶区头颅磁共振波谱的变化，并观察颞叶区的N-乙酰天门冬氨酸（NAA）、NAA/（Cr＋Cho）值。结果 治疗组大鼠学习记忆能力及颞叶区的NAA、NAA/（Cr＋Cho）值较痴呆组明显提高（P<0.01）。结论 皮下注射bFGF能明显提高VD大鼠的学习记忆能力和NAA、NAA/（Cr＋Cho）值。

关键词: 碱性成纤维细胞生长因子, 血管性痴呆, 大鼠, 磁共振波谱

Abstract: Objective To observe the effect of basic fibroblast growth factor (bFGF) on magnetic resonance spectroscopy of vascular dementia (VD) rats.Methods After the VD model was reproduced, the 12 rats were randomly divided into the therapy group and dementia group with 6 animals in each group. Another 6 rats were selected as sham operation group. The VD rats in therapy group were treated with bFGF by hypodermic injection. After 5 weeks, abilities of learning and memory of three groups' rats were tested by Morris water maze. The changes of magnetic resonance spectroscopy and N-acetyl aspartate (NAA), NAA/（Cr＋Cho） in lobus temporalis of VD rats were also observed.Results Abilities of learning and memory of rats significantly improved in the therapy group than that in the dementia group (P<0.01). The values of NAA, NAA/（Cr＋Cho） in lobus temporalis of VD rats significantly increased in the therapy group than that in the dementia group (P<0.01).Conclusion bFGF by hypodermic injection can obviously elevate abilities of learning and memory and the values of NAA, NAA/（Cr＋Cho） in lobus temporalis of VD rats.

Key words: basic fibroblast growth factor (bFGF), vascular dementia, rat, magnetic resonance spectroscopy