《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (01): 82-83.

• 临床研究 • 上一篇    下一篇

脉压、脉压指数与原发性高血压肾损害早期的关系

张盛霞1;赵东太2;宋晓冬2;沈卫萍2   

  1. 1.山东省青岛市第三人民医院内二科，山东青岛市 266041;2.河南省新乡市第一人民医院，河南新乡市 453000
  • 收稿日期:2008-10-20 出版日期:2009-01-01 发布日期:2009-01-01

Relationship between Early Renal Injury and Pulse Pressure in Hypertension Patients

ZHANG Sheng-xia, ZHAO Dong-tai, SONG Xiao-dong, et al   

  1. Qingdao 3rd People's Hospital, Qingdao 266041, Shandong, China
  • Received:2008-10-20 Published:2009-01-01 Online:2009-01-01

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摘要： 目的 探讨脉压、脉压指数与原发性高血压患者的尿微量白蛋白（MAU）、尿β2-微球蛋白（β2-MG）与尿α1-微球蛋白（α1-MG）之间的关系。方法 96例原发性高血压患者检测尿MAU、尿β2-MG以及尿α1-MG，同时计算脉压（PP）与脉压指数（PPI），根据脉压、脉压指数比较肾损害指标。结果 PP>65 mmHg(1 mmHg=0.133 kPa)的高血压患者MAU、β2-MG及α1-MG水平高于PP≤65 mmHg的高血压患者（P<0.05）；PPI>0.5的高血压患者尿MAU、尿β2-MG与尿α1-MG高于PPI≤0.5的高血压患者（P<0.05）。出现肾损伤的患者PP及PPI均大于未出现肾损伤的患者（P<0.05）。结论 原发性高血压患者随着PP和PPI的增大而出现肾损害加重。

关键词: 高血压, 脉压, 脉压指数, 肾损害

Abstract: Objective To evaluate the relationship between the early renal injury and the pulse pressure or pulse pressure index in hypertension patients. Methods The pulse pressure (PP) and the pulse pressure index (PPI) in 96 patients with mild to moderate essential hypertension were calculated and the urine β2-microglobulin (β2-MG), the urine α1-microglobulin (α1-MG), albumin were detected.Results The urine β2-MG, the urine α1-MG and albumin in patients with PP>65 mmHg were higher than those with PP≤65 mmHg （P<0.05）; The urine β2-MG and the α1-MG, albumin in patients with PPI>0.5 were higher than those with PPI≤0.5 （P<0.05）. While the patients with renal injury complicated with a higher PP or PPI than those without renal injury （P<0.05）. Conclusion The renal injury is more severe in patients with higher pulse pressure and pulse pressure index.

Key words: hypertension, pulse pressure, pulse pressure index, renal injury