《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (05): 468-469.

• 临床研究 • 上一篇    下一篇

高压氧对脑出血患者血清黏附分子的影响

李胜利;朱向阳;董政协;周永;李嘉;黄怀宇   

  1. 南通市第一人民医院(南通大学第二附属医院)神经内科，江苏南通市 226001
  • 收稿日期:2009-03-02 出版日期:2009-05-01 发布日期:2009-05-01

Effects of Hyperbaric Oxygen on Serum Adhesion Molecules in Acute Intracerebral Hemorrhage

LI Sheng-li, ZHU Xiang-yang, DONG Zheng-xie, et al   

  1. Department of Neurology, The Second Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China
  • Received:2009-03-02 Published:2009-05-01 Online:2009-05-01

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摘要： 目的 探讨高压氧（HBO）对脑出血患者血清黏附分子的影响。方法 将66例脑出血患者分为常规治疗组33例和HBO治疗组33例，分别于治疗前后测定血清细胞间黏附分子-1（ICAM-1）、血管细胞黏附分子-1（VCAM-1）、E-选择素（E-selectin），并与30例正常者对照。结果 治疗前所有患者血清ICAM-1、VCAM-1、E-selectin水平均明显高于正常对照组（P<0.01），治疗后两组各项水平均下降，HBO治疗组下降较常规治疗组更多（P<0.05）。结论 HBO治疗能降低血清黏附分子水平。

关键词: 高压氧, 脑出血, 细胞间黏附分子-1（ICAM-1）, 血管细胞黏附分子-1（VCAM-1）, E-选择素

Abstract: Objective To study the effects of hyperbaric oxygen （HBO） therapy in patients with acute intracerebral hemorrhage on serum adhesion molecules. Methods 66 cases with acute intracerebral hemorrhage were divided into routine treatment group (n=33) and HBO treatment group (n=33). 30 health persons were selected as normal trontrol. The level of adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin, were measured before and after treatment. Results The levels of adhesion molecules in routine and HBO treatment groups were higher than those in normal control group when hospitalized (P<0.01). All the adhesion molecules levels in two treatment group were decreased after the treatment, and more significantly in HBO group (P<0.05). Conclusion HBO therapy may ameliorate the adhesion molecule abnormalities after intracerebral hemorrhage.

Key words: hyperbaric oxygen, intracerebral hemorrhage, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin