《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (05): 436-438.

• 基础研究 • 上一篇    下一篇

丹参舒颈丸对颈髓受压模型大鼠病理变化的影响

田伟1,2;孙岚1,2;王征美1,2;张玉辉3;赵永青4   

  1. 1.首都医科大学康复医学院，北京市 100068;2.中国康复研究中心北京博爱医院中西医结合科,北京市 100068;3.中国中医科学院基础理论研究所,北京市 100700;4.中国人民武装警察部队医学院附属医院脑系科中心,天津市 300162
  • 收稿日期:2009-01-14 修回日期:2009-03-16 出版日期:2009-05-01 发布日期:2009-05-01

Effects of Danshen Shujingwan on Cervical Spinal Cord Compression in Rats

TIAN Wei，SUN Lan，WANG Zheng-mei， et al   

  1. Department of Integrated Traditional and Western Medicine, Capital Medical University School of Rehabilitation Medicine, Beijing Charity Hospital, China Rehabilitation Research Centre, Beijing 100068, China
  • Received:2009-01-14 Revised:2009-03-16 Published:2009-05-01 Online:2009-05-01

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摘要： 目的 观察丹参舒颈丸对大鼠颈髓受压模型损伤区脊髓组织病理学变化的影响。方法 健康6周龄清洁级SD雄性大鼠60只，50只在第4、5颈椎间植入硅胶颗粒，复制脊髓压迫模型。将造模后大鼠随机分为5组：丹参舒颈丸高、中、低剂量组、颈复康组和模型组，每组10只。另10只大鼠为假手术组。造模后1周开始灌胃给药，共30 d。对颈髓受压区行光学显微镜的观察和半定量图像分析。结果 药物干预组损伤程度及范围显著小于模型组（P<0.001），残存正常神经元的数量明显多于模型组（P<0.01）。结论 丹参舒颈丸可以减轻颈髓受压模型大鼠受压区的损伤，保护神经元。

关键词: 脊髓损伤, 病理学, 丹参舒颈丸, 大鼠

Abstract: Objective To study the effects of Danshen Shujingwan on cervical cord compression in rats. Methods 60 healthy male SD rats of 8 weeks old were randomly divided into 6 groups: sham group (N group), model group (M group), DSW groups of high, medium and low dosages, and group treated with Jingfukang (J group), with 10 rats in each. The cervical cord compression models were established by transplanted silica gel. From 7 d after model establishments, the rats were respectively treated with drug by gavage for 30 d. They were observed pathologically. Results The extent and scope of damage were less in the treatment groups than in the model group (P<0.001), while the number of normal neurons remained more in the treatment groups (P<0.01).Conclusion DSW can decrease the damage after cervical spinal cord compression, protect the neurons from injuring.

Key words: spinal cord injury, pathology, Danshen Shujingwan, rat