《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (08): 466-467.

• 基础研究 • 上一篇    下一篇

阿尼西坦对缺血再灌注脑损伤小鼠学习记忆功能的影响

田国庆1; 卢贺起2; 郭赛珊1   

  1. 1.北京协和医院 北京市 100730;2.中医研究院基础理论研究所 北京市 100007
  • 收稿日期:2004-05-26 出版日期:2004-08-25 发布日期:2004-08-25

Effect of aniracetam on learning and memory dysfunction in mice with cerebral ischemia/reperfusion injury

TIAN Guo-qing, LU He-qi, GUO Sai-shan   

  1. Department of TCM, Peking Union Medical College Hospital, Beijing 100730, China.
  • Received:2004-05-26 Published:2004-08-25 Online:2004-08-25

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被引次数

1

摘要： 目的观察阿尼西坦对缺血再灌注脑损伤小鼠学习记忆功能的影响。方法 48只小鼠随机分为正常对照组、假手术组、模型组及阿尼西坦给药组 ,每组 12只。阿尼西坦组灌胃阿尼西坦 0.5ml/d ,其余各组灌胃蒸馏水 0.5ml/d ,手术前后各7d,共14d。采用双侧颈总动脉夹闭术 ,建立缺血再灌注脑损伤小鼠模型。以Morris水迷宫测试小鼠学习记忆功能。结果模型组小鼠潜伏期较正常对照组及假手术组延长(P<0.05);阿尼西坦组小鼠潜伏期缩短 ,与模型组比较 ,有显著性差异 (P<0.05)。结论阿尼西坦具有改善缺血再灌注脑损伤小鼠学习记忆功能的作用。

关键词: 阿尼西坦, 学习记忆, 缺血再灌注, 小鼠

Abstract: ObjectiveTo investigate the effects of Aniracetam on learning and memory dysfunction in mice with cerebral ischemia/reperfusion injury. Methods48 mice were randomly divided into control group, sham operated group, model group and Aniracetam group, with 12 mice each. Mice model of cerebral ischemia/reperfusion injury was established by bilateral common carotid artery blocking. The learning and memory function was tested by Morris water maze.ResultsThe latent period in the model group was longer than that in the normal group and the sham operated group (P<0.05). Aniracetam could shorten the latent period significantly as compared with those in the model group (P<0.05). ConclusionAniracetam has effects in improving learning and memory function in cerebral ischemia/reperfusion injured mice.

Key words: aniracetam, learning and memory, ischemia/reperfusion, mice