《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (04): 338-340.

• 综述 • 上一篇    下一篇

脑性瘫痪患儿伴发临床下癫痫样放电临床综述

陈军1;王珂1;侯梅1;王强2   

  1. 1. 青岛市儿童医院，青岛市残疾儿童医疗康复中心，山东青岛市 266011;2. 青岛大学医学院附属医院康复医学科，山东青岛市 266003
  • 收稿日期:2008-12-06 出版日期:2009-04-01 发布日期:2009-04-01

Clinical Review of Subclinical Epileptiform Discharges in Children with Cerebral Palsy

CHEN Jun, WANG Ke, HOU Mei, et al   

  1. Qingdao Rehabilitation Center for Disabled Children, Qingdao Children Hospital, Qingdao 266011, Shandong, China
  • Received:2008-12-06 Published:2009-04-01 Online:2009-04-01

PDF (PC)

被引次数

10

摘要： 临床下癫痫样放电对脑瘫患儿的影响不容忽视。据来自医院或康复机构的报道，脑瘫患儿临床下癫痫样放电的发生率为18%～40%，尤其见于痉挛型偏瘫和双瘫患儿，局灶性或多灶性放电占多数，中央颞区、顶区多见。皮质损伤及存在合并症是脑瘫伴发临床下癫痫样放电的危险因素。阵发性或长期大量的临床下癫痫样放电会导致皮质神经元死亡，引起一过性或慢性认知损伤，影响脑瘫患儿的预后。丙戊酸、苯二氮卓类、拉莫三嗪对癫痫样放电有一定的抑制作用，促肾上腺皮质激素和糖皮质激素对抑制癫痫样放电有很强的作用。

关键词: 脑性瘫痪, 临床下癫痫样放电, 临床特征, 治疗, 综述

Abstract: The effects of subclinical epileptiform discharges (SEDs) on children with cerebral palsy cannot be ignored. Data from neurodevelopmental clinic studies showed that the overall incidence of SEDs in cerebral palsy was 18%～40%, with the highest in spastic hemiplegia and diplegia. The major pattern of SEDs was focal and multifocal, and was usually found in centro-temporal and parietal regions. The cortex impairment and other complications were risk factors related to SEDs in cerebral palsy. Paroxysmal or frequent long-time SEDs, with the Results of transient or chronic cognitive impairment, have been found to lead to subsequent death of cortical neurons of cerebral palsy patients thereby worsening their prognosis. Valproic acid (VPA), benzodiazepines (BZs) and lamotrigine (LTG) have a role in inhibiting SEDs, while adrenocorticotropic hormone (ACTH) and glucocorticoids have a great role in it.

Key words: cerebral palsy, subclinical epileptiform discharges, clinical nature, treatment, review