《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (03): 236-237.

• 基础研究 • 上一篇    下一篇

胰岛素样生长因子结合蛋白2在胶质瘤中的表达及临床意义

崔云;徐丽;王军梅   

  1. 首都医科大学附属北京天坛医院，北京市神经外科研究所，北京市 100050
  • 收稿日期:2008-11-05 出版日期:2009-03-01 发布日期:2009-03-01

Expression of Insulin-like Growth Factor Binding Protein 2 in Glioma: Related to Prognoses

CUI Yun, XU Li, WANG Jun-mei   

  1. Beijing Neurosurgical Institute, Beijing Tiantan Hospitail, Capital Medical University, Beijing 100050, China
  • Received:2008-11-05 Published:2009-03-01 Online:2009-03-01

PDF (PC)

被引次数

3

摘要： 目的 探讨不同病理分级胶质瘤中胰岛素样生长因子结合蛋白2（IGFBP-2）的表达情况，以及与其他分子及临床预后的相关性。方法 应用免疫组化法检测45例不同病理分级胶质瘤组织中IGFBP-2的表达，并分析其表达与病理分级、肿瘤组织P53和Ki-67、患者预后的关系。结果 IGFBP-2在肿瘤组织中的表达随肿瘤病理分级升高而升高，与P53和Ki-67的表达显著相关，肿瘤IGFBP-2表达高的患者复发期和总生存期均明显缩短。结论 肿瘤组织IGFBP-2的表达情况是辅助胶质瘤诊断和预测预后的有效指标。

关键词: 胶质瘤, 胰岛素样生长因子结合蛋白2（IGFBP-2）, 预后, 肿瘤分级, P53, Ki-67, 复发, 生存期

Abstract: Objective To determine the levels of insulin-like growth factor binding protein-2 (IGFBP-2) in glioma tumor tissue and their clinical significance. Methods The levels of IGFBP-2 in glioma samples from 45 patients were detected with immunohistochemistry. Their correlation with tumor grade, p53 and Ki67 expression levels and the outcome of patients were tested. Results IGFBP-2 increased in glioma tissue in a grade-dependent manner, and significantly correlated with p53 and Ki67 expression. High IGFBP-2 level is significantly associated with earlier tumor recurrence and shorter overall survival. Conclusion Tumor IGFBP-2 levels can supply more prognostic information to the tumor grading system.

Key words: glioma, insulin-like growth factor binding protein-2 (IGFBP-2), prognosis, tumor grade, P53, Ki-67, recurrence, survival