《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (08): 767-769.

• 临床研究 • 上一篇    下一篇

左室中层缩短率与高血压者左室构型和左室重量关系的研究

苗冬梅;叶平;高鹏;张今尧;肖文凯   

  1. 解放军总医院老年心血管二科，北京市 100853
  • 收稿日期:2009-05-05 修回日期:2009-06-22 出版日期:2009-08-01 发布日期:2009-08-01
  • 通讯作者: 叶平

Relationship between Left Ventricular Remodeling and Systolic Function Assessed by Left Ventricular Mid-wall Fractional Shortening

MIAO Dong-mei,YE Ping,GAO Peng,et al   

  1. Department 2 of Gerontic Cardiology, PLA General Hospital,Beijing 100853, China
  • Received:2009-05-05 Revised:2009-06-22 Published:2009-08-01 Online:2009-08-01

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摘要： 目的 探讨左室中层缩短率与高血压患者左室构型及左室重量的关系。方法 收集2008年10月～2008年12月的51例患者入高血压病组，47名健康体检者作为正常对照组。分析临床特点，同时行超声心动图，采用常规M型测定左室舒张末内径、收缩末内径、左室舒张末和收缩末容量，软件计算射血分数、缩短分数、左室中层缩短率以及相对室壁厚度和左室重量。根据相对室壁厚度和左室重量将高血压患者分为4个亚组：正常结构组、向心性重构组、向心性肥厚组和离心性肥厚组。分析各组的收缩功能指标，观察左室中层缩短率与左室相对室壁厚度和左室重量的相关性。结果 ①高血压组与对照组比较：高血压组室间隔舒张末内径显著增加(1.18±0.28 vs 0.95±0.13，P<0.001)、后壁舒张末内径明显增加(1.01±0.17 vs 0.89±0.17, P<0.01)、左室中层缩短率明显降低( 18.0±4.9 vs 22.3±5.9, P<0.01)。②高血压不同构型亚组的收缩功能和左室构型的比较：左室舒张期室间隔厚度、相对室壁厚度、左室重量差异有统计学意义，而舒张末左室内径、射血分数以及缩短分数差异无统计学意义，左室中层缩短率有统计学差异(P<0.05)。③高血压组左室收缩功能与相对室壁厚度和左室重量的相关性：左室中层缩短率与相对室壁厚度相关r=-0.42, P<0.05)、左室中层缩短率与左室重量指数显著相关r=0.67, P<0.01)、而射血分数、缩短分数与左室重量、相对室壁厚度之间无相关关系。结论 左室壁内缩短分数可以更有效的评价早期高血压患者的收缩功能，并与其相对室壁厚度和左室重量有相关关系。

关键词: 高血压, 室壁内缩短分数, 左室重构

Abstract: Objective To investigate the correlation between left ventricular remodeling and systolic function by mid-wall fractional shortening(mFS).Methods 51 cases of hypertension and 47 cases of healthy volunteers were enrolled and systolic parameters were measured as ejection fraction(EF), fractional shortening(FS) and mFS. Acorrding to left ventricular remodeling parameteres inclulding LVMI and RWT, hypertension group was divided into four subgroups. The correlation among these parameters were analyzed.Results Thicker left ventricular wall and lower mFS in patient with hypertension compaired with those in controll (P<0.05). There were negative correlation between mFS and RWTr=-0.42, P<0.05) and positive correlation between mFS and LVMI r=-0.67, P<0.01).Conclusion mFS is a valuable parameter compared with traditional parameteres such as EF and FS. There is a linear association between parameteres of ventricular remodeling and systolic function assessed by mFS in early stage of hypertension.

Key words: hypertension, midwall fraction, left ventricle remodeling