《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (09): 833-834.

• 基础研究 • 上一篇    下一篇

莫诺苷对局灶性脑缺血再灌注大鼠皮层总抗氧化能力影响

艾厚喜1;李蕾1;许栋明2;王文1;王培昌1;张丽1;李林1   

  1. 1.首都医科大学宣武医院，北京市 100053;2.科技部火炬高技术产业开发中心，北京市 100038
  • 收稿日期:2009-07-01 修回日期:2009-08-05 出版日期:2009-09-01 发布日期:2009-09-01
  • 通讯作者: 王文、王培昌

Effects of Morroniside on Total Antioxidative Capacity in Rat Cortex with Focal Cerebral Ischemia/Reperfusion

AI Hou-xi,LI Lei,XU Dong-ming,et al   

  1. Xuanwu Hospital of Capital Medical University， Beijing 100053, China
  • Received:2009-07-01 Revised:2009-08-05 Published:2009-09-01 Online:2009-09-01

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摘要： 目的 研究山茱萸有效成分莫诺苷对局灶性脑缺血再灌注大鼠皮层总抗氧化能力的影响。方法 用线栓法制备大鼠局灶性脑缺血再灌注模型，采用分光光度法检测脑组织总抗氧化能力变化。结果 莫诺苷（270 mg/kg）能增强大鼠总抗氧化能力。结论 莫诺苷能通过增强大鼠皮层总抗氧化能力发挥神经保护作用。

关键词: 莫诺苷, 缺血再灌注, 总抗氧化能力, 神经保护

Abstract: Objective To investigate the effects of morroniside on total antioxidative capacity (T-AOC) in rat cortex with focal cerebral ischemia/reperfusion. Methods The animal model was induced with occlusion of middle cerebral artery. The T-AOC was detected with spectrophotometer. Results Compared with model group, morroniside （270 mg/kg） increased the T-AOC significantly. Conclusion Morroniside may take the neuroprotection through increased T-AOC of rat cortex.

Key words: morroniside, ischemia/reperfusion, total antioxidative capacity, neuroprotection