《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (10): 918-920.

• 专题 • 上一篇    下一篇

持续性多巴胺能刺激对帕金森病非运动症状作用的前瞻性研究

冯涛;张璇;刘萍;王拥军   

  1. 首都医科大学附属北京天坛医院神经内科，北京市 100050
  • 收稿日期:2009-08-05 出版日期:2009-10-01 发布日期:2009-10-01

Effect of Continuous Dopaminergic Stimulation on Non-motor Symptoms in Patients with Parkinson's Disease

FENG Tao,ZHANG Xuan,LIU Ping,et al   

  1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
  • Received:2009-08-05 Published:2009-10-01 Online:2009-10-01

PDF (PC)

被引次数

11

摘要： 目的 评价以复方多巴联合恩他卡朋的持续性多巴胺能刺激疗法对于帕金森病非运动症状的疗效。方法 筛选58例已出现运动波动、合并非运动症状的帕金森病患者，在原来服用复方多巴的基础上，联合恩他卡朋的方法进行持续性多巴胺能刺激治疗，在治疗前和治疗8周后进行基线和研究终点的评测，包括非运动症状筛查量表(NMSS)、PD疲劳量表(PFS)、汉密尔顿抑郁量表(HAMD)、统一PD评测量表(UPDRS)和匹兹堡睡眠障碍量表(PSQI)等量表评测，并对基线和终点的各量表评分进行比较。结果 受试者在研究终点的NMSS量表总分(48.2±24.6)低于基线的(59.4±25.6)(P<0.05)，其中在泌尿功能、性功能、抑郁和焦虑、睡眠和疲劳等分量表上的终点评分低于基线评分(P<0.05)；在胃肠道功能、心血管功能、幻觉和错觉、注意力和记忆力等分量表上的终点评分与基线评分差异无统计学意义(P>0.05)。受试者研究终点的HAMD、PFS、PSQI等量表评分均低于基线评分(P<0.05)。结论 持续性多巴胺能刺激疗法有助于改善帕金森病的部分非运动症状。

关键词: 帕金森病, 左旋多巴, 非运动症状, 恩他卡朋

Abstract: Objective To evaluate the effect of continuous dopaminergic stimulation on the non-motor symptoms. Methods Fifty-eight patients with Parkinson's disease(PD) following motor fluctuation and non-motor symptom were enrolled in this study. The subjects were treated with levodopa/carbidopa and entacopone for eight weeks. The scores of NMSS, PD fatigue scale, HAMD and Pittsburgh Sleep Quality Index (PSQI) were compared between baseline and endpoint.Results The total scores of NMSS decreased significantly from baseline to endpoint (P<0.05). The scores of endpoint were significantly lower than those of baseline in the urinary, sexual function, depression/anxiety and sleep/fatigue subscale of NMSS; however, there was no significant difference between baseline and endpoint in the gastrointestinal, cardiovascular, hallucination/delusions, attention/memory subscales of NMSS. The scores of endpoint were significantly lower than those of baseline in HAMD, PD fatigue scale and PSQI.Conclusion The continuous dopaminergic stimulation treatment with levodopa/carbidopa and entacapone may improve some respects of non-motor symptom of PD.

Key words: Parkinson's disease, levodopa, non-motor, entacopone