《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (12): 1133-1134.

• 基础研究 • 上一篇    下一篇

关节松动术结合股四头肌训练对兔膝骨性关节炎关节液中NO及TNF水平的影响

樊留博;马利中;田瑛   

  1. 浙江省台州医院康复医学科，浙江台州市 317000
  • 收稿日期:2009-07-13 修回日期:2009-09-30 出版日期:2009-12-25 发布日期:2009-12-25

Effect of Joint Mobilization and Quadriceps Setting on NO and TNF of Experimental Knee Osteoarthritis in Rabbits

FAN Liu-bo,MA Li-zhong,TIAN Ying   

  1. Taizhou Hospital, Taizhou 317000, Zhejiang, China
  • Received:2009-07-13 Revised:2009-09-30 Published:2009-12-25 Online:2009-12-25

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被引次数

34

摘要： 目的 探讨关节松动术结合股四头肌训练对兔膝骨性关节炎(KOA)的影响。方法 将32只大耳白兔随机分为4个组，采用兔膝关节腔内注入木瓜蛋白酶造成骨性关节炎病理模型，以关节松动术结合股四头肌训练康复治疗进行对比观察，利用兔跑跳装置给动物施加运动训练，连续治疗6周后分别取材。采用双抗体夹心酶联免疫吸附实验(ELISA)法分别测定各组兔膝关节液中一氧化氮(NO)及肿瘤坏死因子(TNF)的水平。结果 治疗组关节液中NO 和TNF均呈低表达，与对照组相比具有非常显著性差异( P<0.01)。结论 关节松动术结合股四头肌训练可降低KOA关节液中NO和TNF的水平。

关键词: 骨性关节炎, 一氧化氮, 肿瘤坏死因子, 关节松动术, 实验研究, 兔

Abstract: Objective To explore the effect of joint mobilization and quadriceps setting on nitric oxide(NO) and tumor necrosis factor(TNF) of the experimental knee osteoarthritis in rabbits. Methods Rabbits model of knee osteoarthritis was induced by papain. 32 rabbits were divided into 4 groups randomly, 8 in each group. The changes of contents of NO and TNF in synovia were detected.Results Expression of NO and TNF in synovia of all treatment groups decreased compared to the control group(P<0.01).Conclusion Joint mobilization and quadriceps setting can decrease the level of NO and TNF in synovia.

Key words: osteoarthritis, nitric oxide(NO), tumor necrosis factor(TNF), joint mobilization, empirical study, rabbit