《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (10): 901-904.

• 专题 •    下一篇

脑缺血再灌注后血脑屏障损伤机制及药物保护作用的研究进展

李蕾1;许栋明2;王文1;王培昌1;艾厚喜1;张丽1;李林1   

  1. 1. 首都医科大学宣武医院，北京市 100053;2. 科技部火炬高技术产业开发中心，北京市 100038
  • 收稿日期:2009-07-10 出版日期:2009-10-01 发布日期:2009-10-01

Advance in Damage Mechanism on Blood Brain Barrier after Cerebral Ischemia-reperfusion and Neuroprotective Drugs (review)

LI Lei,XU Dong-ming,WANG Wen,et al   

  1. Xuanwu Hospital of Capital Medical University; Torch High Technology Industry Development Center，The Ministry of Science and Technology of the P.R.C.，Beijing 100038，China
  • Received:2009-07-10 Published:2009-10-01 Online:2009-10-01

PDF (PC)

被引次数

38

摘要： 脑缺血再灌注导致血脑屏障破坏，从而引起脑出血和脑水肿。与此同时机体内释放大量的细胞和化学因子可以调控血脑屏障的开放。目前研究表明，脑缺血再灌注后血脑屏障损伤的主要机制为炎症因子的浸润，蛋白酶的水解作用以及水通道蛋白的开放等。通过对以上机制的深入研究有助于开发新的脑保护药物，并进一步明确各种脑保护药物的治疗靶点和疗效。

关键词: 脑缺血再灌注, 血脑屏障, 药物, 综述

Abstract: Cerebral ischemia-reperfusion Results in breakdown on construction and function of blood brain barrier, leading to hemorrhage transformation and brain edema. At the same time, generous cytokines and chemokines released after cerebral ischemia-reperfusion can regulate the opening of the blood brain barrier. Many current studies showed that the major damage mechanisms on blood brain barrier are inflammatory infiltration, proteolysis, opening aquaporin and so on. The deep research on the mechanism contributes to explore new neuroprotective drugs, and further identify the target and therapeutic effect of drug treatment.

Key words: cerebral ischemia-reperfusion, blood brain barrier, drug, review