《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (10): 913-915.

• 专题 • 上一篇    下一篇

莫诺苷对大鼠局灶性脑缺血再灌注模型脑梗死体积的影响

刘秀平1;许栋明3;王文2;王烈群1;张丽2;艾厚喜2;李林2   

  1. 1. 内蒙古医学院，内蒙古呼和浩特市 010059;2. 首都医科大学宣武医院，北京市 100053;3. 科技部火炬高技术产业开发中心，北京市 100038
  • 收稿日期:2009-08-31 出版日期:2009-10-01 发布日期:2009-10-01
  • 通讯作者: 王文

Effect of Morroniside on Cerebral Infarction Volume in Focal Cerebral Ischemia-reperfusion Rats

LIU Xiu-ping,XU Dong-ming,WANG Wen,et al   

  1. Inner Mogolia Medical College, Huhhot 010059, China
  • Received:2009-08-31 Published:2009-10-01 Online:2009-10-01

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摘要： 目的 观察莫诺苷对大脑中动脉阻塞法(MACO)致脑缺血再灌注模型大鼠脑梗死体积的影响。方法 用线栓法制备局灶性脑缺血再灌注大鼠模型，缺血30 min，再灌注7 d。采用2, 3, 5-氯化三苯基四氮唑(TTC) 染色，检测大鼠的脑梗死体积。结果 与假手术组相比，模型组及给药组出现明显梗死灶；与模型组相比，莫诺苷（90 mg/kg，270 mg/kg）脑梗死体积显著减少，维生素E（35 mg/kg）组脑梗死体积未出现明显改变。结论 莫诺苷可减少局灶性脑缺血再灌注大鼠脑梗死体积，对脑缺血再灌注损伤有保护作用。

关键词: 莫诺苷, 脑缺血再灌注, 脑梗死体积

Abstract: Objective To observe the effect of morroniside on cerebral infarction volume in focal cerebral ischemia-reperfusion rat model.Methods The animal model was induced by occlusion of middle cerebral artery with suture embolus, ischemia for 30 minutes, and reperfusion for 7 days. The infarction volume was measured by 2,3,5-triphenyltetrazolium chloride(TTC) staining technique.Results Compared with sham operation group, the cerebral infarction volume ratios increased obviously in model group and in the drug-treated（90 mg/kg，270 mg/kg）groups. Compared with model group, the cerebral infarction volume ratios decreased obviously in the morroniside-treated（90 mg/kg，270 mg/kg）group,while the cerebral infarction volume ratios in vitamin E-treated（35 mg/kg）group didn't change.Conclusion Morroniside may decrease the cerebral infarction volume after cerebral ischemia-reperfusion. It possesses protective effect against cerebral ischemia-reperfusion injury.

Key words: morroniside, cerebral infarction, cerebral infarction volume