《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (12): 1150-1152.

• 临床研究 • 上一篇    下一篇

帕金森病疲劳与运动障碍相关性的病例对照研究

张璇1;冯涛1;刘萍1;王雪梅1;陈彪2   

  1. 1.首都医科大学附属北京天坛医院神经内科，北京市 100050;2.首都医科大学宣武医院，北京市 100053
  • 收稿日期:2009-11-25 出版日期:2009-12-25 发布日期:2009-12-25
  • 通讯作者: 冯涛

Relationship between Fatigue and Motor Dysfunction for Parkinson's Disease

ZHANG Xuan,FENG Tao,LIU Ping,et al   

  1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijng 100050, China
  • Received:2009-11-25 Published:2009-12-25 Online:2009-12-25

PDF (PC)

被引次数

5

摘要： 目的 探讨帕金森病(PD)的疲劳症状是否与运动障碍具有相关性。方法 应用疲劳严重度量表(FSS)评测139例PD患者的疲劳症状并分为疲劳组和非疲劳组。分别用统一帕金森病评定量表(UPDRS)、Hohen-Yahr分级、抑郁量表和简易精神状态量表(MMSE)等对两组患者进行比较。应用Spearman法分析帕金森病疲劳与运动障碍的相关性。结果 70例受试的PD患者存在疲劳。疲劳组UPDRS运动分量表评分高于非疲劳组PD患者(25.24±13.95 vs 19.34±11, P<0.05)；肌强直项目评分(6.27±4.60)和运动迟缓项目评分(7.78±6.88)高于非疲劳组相应评分(4.07±3.89和5.51±5.03, P<0.05)；但两组震颤项目评分无显著性差异(P>0.05)。PD患者FSS评分与UPDRS运动分量表评分具有显著性相关(r=0.260，P＜0.05)。结论 疲劳是PD常见非运动症状。PD疲劳的程度与运动障碍程度相关。

关键词: 帕金森病, 疲劳, 运动障碍

Abstract: Objective To investigate the relationship between fatigue and motor dysfunction in patients with Parkinson's disease(PD).Methods 139 PD patients were assessed with Fatigue Severe Scale(FSS) and divived into the fatigue group and non-fatigue group. The motor function, depression and cognitive function were assessed with Unified Pakinson's Disease Rating Scale(UPDRS), Hamilton Depression Scale and mini-mental state examination(MMSE) respectively. The Spearman's rank correlation coefficient was used to evaluate the correlation between fatigue and motor dysfunction.Results 70 patients had fatigue. The UPDRS motor subscale score of the fatigue group was significantly higher than the non-fatigue group (P<0.05). The UPDRS score of rigidity items and bradykinesia items of the fatigue group were significantly higher than those of the non-fatigue group(P<0.05), with no significant difference in UPSRS score of tremor items between the two groups (P>0.05). There was significant correlation between FSS score and UPDRS motor score (P<0.05). Conclusion Fatigue is one of the common symptoms of PD and correlates with motor dysfunction.

Key words: Parkinson's disease, fatigue, motor dysfunction