《中国康复理论与实践》

《中国康复理论与实践》 ›› 2009, Vol. 15 ›› Issue (11): 1041-1043.

• 综述 • 上一篇    下一篇

炎症反应影响脑缺血再灌注损伤的研究进展

刘秀平1,2;许栋明3;王文1;王烈群2;张丽1;艾厚喜1；李林1   

  1. 1.首都医科大学宣武医院，北京市 100053;2.内蒙古医学院，内蒙古呼和浩特市 010059;3.科技部火炬高技术产业开发中心，北京市 100038
  • 收稿日期:2009-09-07 出版日期:2009-11-01 发布日期:2009-11-01
  • 通讯作者: 王文、王烈群

Inflammatory Reaction during Cerebral Ischemia Reperfusion Injury (review)

LIU Xiu-ping,XU Dong-ming,WANG Wen,et al   

  1. Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  • Received:2009-09-07 Published:2009-11-01 Online:2009-11-01

PDF (PC)

被引次数

83

摘要： 脑缺血再灌注损伤是脑损伤的因素之一，而局部过度炎症反应是造成再灌注损伤主要原因之一。许多炎症细胞及炎症介质均参与了炎症反应。本文主要综述炎症细胞、细胞因子、趋化因子、黏附分子等炎症因子对脑组织损伤的影响。

关键词: 脑, 缺血再灌注, 白细胞, 小胶质细胞, 星型胶质细胞, 细胞因子, 趋化因子, 黏附分子

Abstract: The cerebral ischemia reperfusion injury is one of factors in aggravating brain injury, and the inflammatory response is one of the main reasons in the reperfusion injury after acute cerebral ischemia. Inflammation is modulated by many factors such as inflammatory mediators and inflammatory cells that promote brain damage from ischemia injury to reperfusion injury. This paper would review the role of inflammatory cells and mediators such as cytokines, chemotactic factors, adhesion molecules on cerebral tissue injury.

Key words: brain, ischemia reperfusion, leukocytes, astrocytes, microglia, cytokines, chemotactic factors, adhesion molecules