《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (03): 161-162.

• 基础研究 • 上一篇    下一篇

中国汉族人群血管内皮细胞生长因子基因的单核苷酸多态性研究

张英爽; 樊东升; 张华纲; 王晓飞; 张俊; 傅瑜; 康德   

  1. 北京大学第三医院神经内科 北京市 100083
  • 收稿日期:2004-02-13 出版日期:2004-03-25 发布日期:2004-03-25

Single neucleotide polymorphisms of the vascular endothelial growth factor gene in Chinese Han population

Ying-shuang, FAN Dong-sheng, ZHANG Hua-gang, et al   

  1. Department of Neurology, Third Hospital, Peking University, Beijing 100083, China
  • Received:2004-02-13 Published:2004-03-25 Online:2004-03-25

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被引次数

10

摘要： 目的探讨中国汉族人群血管内皮细胞生长因子(VEGF)基因的单核苷酸多态性(SNPs)分布规律。方法应用等位基因特异性扩增技术,对252名中国汉族正常人的VEGF基因SNPs进行检测,并与文献报道的欧洲白人数据进行比较。结果VEGF基因启动子区的多态位点C2578A的基因型频率分布中,CC为48.8%、CA为46.0%、AA为5.2%;C等位基因频率为71.8%,A等位基因频率为28.2%。与欧洲白人相比较,各基因型和等位基因分布存在非常显著性差异(P<0.01)。结论中国汉族人群VEGF基因SNPs与欧洲白人显著不同,中国人低VEGF表达的 2578A/A纯合子明显少于欧洲白人。

关键词: 血管内皮细胞生长因子, 单核苷酸多态性, 中国汉族人群

Abstract: ObjectiveTo determine the distribution of the single neucleutide polymorphisms (SNPs) of the vascular endothelial growth factor (VEGF) gene in Chinese Han population. Methods252 healthy Chinese Han subjects were studied with PCR technique. The results were compared with the data on European Caucasians reported. ResultsThe frequencies of VEGF gene allele C and A were respectively 71.8% and 28.2%. The genotypes of CC, CA and AA were 48.8%, 46.0% and 5.2%, respectively. The frequencies of VEGF promoter 2578A/A polymorphism in Chinese Han population were significantly different from those in European Caucasian population(P<0.01). Conclusion2578A/A homozygote which results to low VEGF expression of Chinese Han subjects is remarkably less than that of European Caucasians.

Key words: vascular endothelial growth factor(VEGF), single neucleotide polymorphisms(SNPs), Chinese Han population