《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (9): 837-839.

• 论文 • 上一篇    下一篇

肝气郁结模型大鼠正电子发射脑功能成像研究

刘子旺1，赵海滨1，张秀静1，单保慈2，刘华2，贺立娟3   

  1. 1.北京中医药大学第三附属医院，北京市 100029；2.中国科学院高能物理研究所，北京市 100039； 3.北京中医药大学东方医院，北京市 100078。
  • 收稿日期:2011-06-03 修回日期:1900-01-01 出版日期:2011-09-25 发布日期:2011-09-25

Findings in Positron Emission Tomography of Brain in Rats with Syndrome of Stagnation of Liver-Qi

LIU Zi-wang, ZHAO Hai-bin,ZHANG Xiu-jing, et al.   

  1. the 3rd Affiliated Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100029, China
  • Received:2011-06-03 Revised:1900-01-01 Published:2011-09-25 Online:2011-09-25

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摘要： 目的探讨肝气郁结证在特定脑区功能的改变。方法10 只Wistar 大鼠采用慢性应激结合孤养方法制备肝气郁结证大鼠模型，分别于造模前后进行氟18 脱氧葡萄糖(18F-FDG)PET 正电子扫描，应用SPM2 图像分析软件对造模前、造模后数据进行双样本t 检验。结果葡萄糖代谢减低脑区(P<0.001)有左侧额叶、顶叶、下丘脑，双侧后扣带回，右侧前扣带回。葡萄糖代谢升高脑区(P<0.001)有左侧海马旁回、岛叶、颞叶、额叶，右侧基底核、丘脑。结论肝气郁结证可引起特定脑区的功能改变。

关键词: 肝气郁结证, 大鼠, 正电子发射计算机断层显像, 脑功能

Abstract: Objective To explore the characteristics of brain function in rats with Stagnation of Liver-qi Syndrome. Methods Model ofStagnation of Liver-qi was made with chronic stress combined with isolated raising in 10 normal Wistar rats. They were scanned with positronemission tomography (PET) before and after modeling. Data analysis was carried out using SPM (statistical parametric mapping 2) inMATLAB software. Results After modeling, the glucose metabolism decreased (P<0.001) in left frontal lobe, parietal lobe, hypothalamus;bilateral posterior cingulate; right anterior cingulate, while the glucose metabolism increased (P<0.001) in left parahippocampal gyrus, insula,temporal lobe, frontal lobe; right basal ganglia, thalamus. Conclusion The function of some cerebral areas can be changed undergoingStagnation of Liver-qi Syndrome.

Key words: Stagnation of Liver-qi Syndrome, rats, positron emission tomography, cerebral function