《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (8): 701-704.

• 论文 • 上一篇    下一篇

GAS6 基因344-35C/T多态性与脑梗死的相关性研究

陈军，赵斌，陈煜森   

  1. 广东医学院附属医院神经内科，广东湛江市 524001。
  • 收稿日期:2011-03-16 修回日期:1900-01-01 出版日期:2011-08-25 发布日期:2011-08-25
  • 通讯作者: 赵斌

Association of 344-35C/T Polymorphism of Growth Arrest-Specific Gene 6 with Cerebral Infarction

CHEN Jun, ZHAO Bin, CHEN Yu-sen.   

  1. Department of Neurology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, China
  • Received:2011-03-16 Revised:1900-01-01 Published:2011-08-25 Online:2011-08-25

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摘要： 目的探讨粤西地区汉族人群中生长停滞特异性基因6 (GAS6 基因)内含子SNP344-35C/T 位点的单核苷酸多态性(SNP)与脑梗死的相关性。方法应用聚合酶链反应-限制性内切酶片段长度多态性分析方法(PCR-RFLP)检测180 例脑梗死患者和150 例健康对照的GAS6 基因内含子SNP344-35C/T 的基因型。结果GAS6 基因内含子SNP344-35C/T 基因型及等位基因频率在病例组与对照组之间无显著性差异(P<0.05)，经性别分层分析发现，女性C等位基因频率(77.9%)高于对照组(66.4%)(P=0.040)；CC基因型频率(61.8%)高于对照组(43.1%)(P=0.036)。结论GAS6 基因内含子SNP344-35C/T 位点与粤西地区汉族女性脑梗死有关，C等位基因是女性脑梗死的危险因素，CC基因型为女性脑梗死的易感基因型。

关键词: 脑梗死, 生长停滞特异性基因6, 单核苷酸多态性

Abstract: Objective To investigate the correlations of the single nucleotide polymorphism (SNP) 344-35C/T of growth arrest-specificgene 6 (GAS6) gene and cerebral infarction in Han population in the western Guangdong province. Methods The restriction fragment lengthpolymorphism (PCR-RFLP) was used to determine the 344-35C/T polymorphism in the intron region of GAS6 gene in the case group (n=180) and healthy control group (n=150). Results There was no significant association between GAS6-344-35C/T and cerebral infarction (P<0.05). After stratified by gender in chi-square test in women population, the frequency of C allele was significantly higher in cases (77.9%)than that in controls (66.4%) (P=0.040); The frequency of the CC genotype was significantly higher in cases (61.8%) than that in controls(43.1%) (P=0.036). Conclusion In Han women in western Guangdong province, C allele of GAS6-344-35C/T polymorphism is a risk factorof cerebral infarction, CC genotype is a susceptible genotype of cerebral infarction.

Key words: cerebral infarction, growth arrest-specific gene 6, single nucleotide polymorphism