《中国康复理论与实践》

《中国康复理论与实践》 ›› 2011, Vol. 17 ›› Issue (7): 679-681.

• 论文 • 上一篇    下一篇

斑蝥酸钠对中晚期肝癌患者生活质量的影响

张爱萍   

  1. 河南省焦作市第二人民医院中医科，河南焦作市 454000。
  • 收稿日期:2011-05-06 修回日期:1900-01-01 出版日期:2011-07-25 发布日期:2011-07-25

Effects of Sodium Cantharidate on Quality of Life in Advanced Liver Cancer Patients

ZHANG Ai-ping.   

  1. Department of Traditional Chinese Medicine, the Second People's Hospital of Jiaozuo, Jiaozuo 454000, Henan, China
  • Received:2011-05-06 Revised:1900-01-01 Published:2011-07-25 Online:2011-07-25

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摘要： 目的观察斑蝥酸钠对中晚期肝癌患者的化疗效果、生活质量以及副作用的影响。方法62 例中晚期原发性肝癌患者分为两组：对照组(n=31)采用5-氟尿嘧啶加顺铂化疗(FP 方案)，观察组(n=31)在FP 方案的同时加用斑蝥酸钠注射液20 ml 静脉点滴。根据WHO实体瘤客观疗效评定标准评价疗效，根据Karnofsky 行为状态评分(KPS)评价生活质量，采用外周血白细胞和血小板计数评价骨髓毒性反应。结果治疗6 周后，观察组缓解率高于对照组，恶化率低于对照组(P<0.05)；观察组生活质量提高稳定率高于对照组(P<0.05)；观察组外周血白细胞和血小板降低程度低于对照组(P<0.05)。结论斑蝥酸钠有助于改善中晚期肝癌患者的临床症状和生活质量，可减少化疗毒副反应。

关键词: 肝癌, 化学疗法, 斑蝥酸钠, 生活质量

Abstract: Objective To explore the effects of sodium cantharidate on quality of life in advanced liver cancer patients. Methods 62 patientswith advanced liver cancer were divided into two groups: the control group (n=31) received 5-fluorouracil and cisplatinum chemotherapy,while the observation group (n=31) received sodium cantharidate 20 ml in addition. WHO Response Evaluation Criteria in Solid Tumorswas used to assess the theraputical effect, Karnofsky Performance Status to the quality of life, and white blood cell count and plateletcount were to the toxicity of the treatment. Results The observation group had a higher partial remission and lower progressive disease thanthe control group (P<0.05) after the treatment. The quality of life for the observation group improved better than the control group (P<0.05).The white blood cell count and platelet count decreased less in the observation group than in the control group (P<0.05). Conclusion Sodi-um cantharidate may relief symptom, improve quality of life and reduce toxicity for the patients accepted chemotherapy for advanced livercancer.

Key words: liver cancer, chemotherapy, sodium cantharidate, quality of life