《中国康复理论与实践》

《中国康复理论与实践》 ›› 2004, Vol. 10 ›› Issue (06): 343-345.

• 基础研究 • 上一篇    下一篇

滋补脾阴方药治疗大鼠脊髓损伤实验研究

王鸿飞1; 富灵杰2; 战丽彬1; 郑连杰1; 刘用楫1; 苗艳颖3   

  1. 1.大连医科大学第二附属医院骨科 辽宁大连市 116023;2.大连医科大学2001级研究生班 辽宁大连市 116023;3.北京大学医学部 北京市 100000
  • 收稿日期:2004-02-24 出版日期:2004-06-25 发布日期:2004-06-25

Experimental study of nourishing Piyin Remedy on rat with spinal cord injury

WANG Hong-fei, FU Ling-jie, ZHAN Li-bin, et al   

  1. The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning, China
  • Received:2004-02-24 Published:2004-06-25 Online:2004-06-25

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被引次数

34

摘要： 目的探讨滋补脾阴方药对实验性大鼠脊髓损伤的作用和机理。方法32只健康SD大鼠随机分为滋补脾阴方药组和损伤组,采用改良Allen氏装置建立大鼠T8—T9节段脊髓不完全性损伤动物模型。通过脊髓神经功能、体感诱发电位、辣根过氧化酶示踪、大体观察、组织学及超微结构等检查,对比两组动物的差异。结果与损伤组相比,滋补脾阴方药组大鼠的脊髓神经功能评分、体感诱发电位、脊髓运输能力、大体观察、组织形态计量分析、髓鞘和神经元细胞结构等皆有明显改善。结论滋补脾阴方药能明显阻止脊髓的继发性损伤,促进脊髓损伤大鼠神经功能的恢复。

关键词: 脊髓损伤, 滋补脾阴方药, 大鼠

Abstract: ObjectiveTo study the therapeutic effect and mechanisms of nourishing Piyin Remedy (nPR) on experimental rat spinal cord injury.MethodsThirty-two healthy SD rats were divided into 2 equal groups randomly: nPR group and injured group. Animal model of incomplete injury of spinal cord was made by Allen's equipment on rat's T8—T9 segment. The spinal nerve function,SEP,retrograde and label technique of horse radish peroxidase,gross observation,histological and morphometric analysis were taken as the observed indices.ResultsThe value of observed indices of nPR group were improved evidently compared with injured group.ConclusionNourishing Piyin Remede can hold back the secondary spinal cord injury and accelerate the recovery of spinal nerve function.

Key words: spinal cord injury (SCI), nourishing Piyin Remedy, rat