《中国康复理论与实践》

《中国康复理论与实践》 ›› 2003, Vol. 9 ›› Issue (10): 612-613.

• 脊髓损伤康复 • 上一篇    下一篇

阿法骨化醇及二膦酸盐类药物对脊髓损伤患者骨密度的影响

徐基民; 纪树荣; 许健鹏; 孙岚; 佟艳铭; 崇敬   

  1. 北京博爱医院 北京市 100068
  • 收稿日期:2003-07-17 出版日期:2003-10-25 发布日期:2003-10-25

Effects of alfa calcidol and diphosphonates on the BMD of patients with spinal cord injury

XU Ji-min, JI Shu-rong, XU Jian-peng,et al   

  1. Beijing Charity Hospital, Beijing 100068, China
  • Received:2003-07-17 Published:2003-10-25 Online:2003-10-25

PDF (PC)

被引次数

6

摘要： 目的探讨阿法骨化醇及二膦酸盐类药物对脊髓损伤患者骨密度的影响。方法分别比较31例口服阿法骨化醇与42例未口服该药的脊髓损伤患者,以及22例口服二膦酸盐类药物与24例未口服该药的脊髓损伤患者第4腰椎和股骨近端及其分区骨密度变化的差异。结果是否口服阿法骨化醇对脊髓损伤患者骨密度的保持无显著影响;但口服二膦酸盐类药物患者的股骨近端(total)骨密度较未口服该药物患者下降少,两者的差异具有显著性意义(P<0.05)。结论口服二膦酸盐类药物对股骨近端的骨密度变化有保护作用。

关键词: 脊髓损伤, 骨密度, 骨质疏松症, 二膦酸盐类

Abstract: ObjectiveTo study effects of oral administering alfa calcidol and diphosphonates on the bone mineral density (BMD) of patients with spinal cord injury (SCI).MethodsChanges of BMD of the 4th lumbar spine (L4), the proximal femur (total) and all of its subareas were studied between SCI cases of taking (n=31) and not taking (n=42) alfa calcidol. Changes of BMD between cases of taking diphosphonates (n=22) and not taking (n=24) were also compared.ResultsThere were no significant differences in BMD of L4, the proximal femur and all of its subareas between SCI cases of taking and not taking alfa calcidol. While there was a significant difference in BMD of the proximal femur (total) between cases of taking and not taking diphosphonates (P<0.05), and the reducing degree of BMD in the former is less than that in the latter.Conclusion Oral administering diphosphonates has a protective effect on SCI patients' BMD of the proximal femur.

Key words: spinal cord injury (SCI), bone mineral density (BMD), osteoporosis, diphosphonates