《中国康复理论与实践》

《中国康复理论与实践》 ›› 2003, Vol. 9 ›› Issue (06): 346-347.

• 基础研究 • 上一篇    下一篇

血清CA125与抗子宫内膜抗体联合检测诊断子宫内膜异位症

施晓; 章波儿; 唐禹馨; 孙运明; 沈忠海   

  1. 浙江省舟山市妇幼保健院 浙江舟山市 316000
  • 收稿日期:2003-01-23 出版日期:2003-06-25 发布日期:2003-06-25

Evaluation of serum CA125 and endometrial antibody for the diagnosis of endometriosis

SHI Xiao,ZHANG Bo-er,TANG Yu-xin,et al   

  1. Zhoushan Women and Children Health Institute,Zhoushan 316000,Zhejiang,China
  • Received:2003-01-23 Published:2003-06-25 Online:2003-06-25

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摘要： 目的探讨血清CA125与抗子宫内膜抗体(endometrial antibody,EMAb)联合检测对子宫内膜异位症的诊断价值。方法对2001年1月—2001年11月在本科住院需手术的2 16例患者于术前行CA125与抗子宫内膜抗体测定,根据术后病理确诊结果将患者分为内异症组(48例)和对照组(168例)。结果CA125阳性率内异症组为58.3%,对照组为12.5%,两组间有非常显著性差异(P<0.01)。EMAb阳性率内异症组为31.3%,对照组为14.3%,两组间亦有非常显著性差异(P<0.01)。CA125单独测定的敏感性为58.3%,特异性为87.5%;EMAb单独测定的敏感性为31.3%,特异性为85.7%。如以其中之一阳性作为诊断标准,则敏感性为64.6%,特异性为 73.2%。如以两者均为阳性作为诊断标准,则敏感性为25.0%,特异性为100%。结论测定血清中CA125及EMAb水平对子宫内膜异位症有较好的辅助诊断价值,联合测定则更能提高诊断的准确性。

关键词: 抗子宫内膜抗体, 子宫内膜异位症, 诊断

Abstract: ObjectiveTo discuss the clinical value of serum CA125 and endometrial antibody (EMAb) for the diagnosis of endometriosis.Methods216 patients were determined by the presences of CA125 and EMAb before operation.ResultsAll cases were diagnosed by pathology after operation. CA125 positive rate in the endometriosis group was 58.3% and that in the control group was 12.5%. The difference between two groups was significant (P<0.01).EMAb positive rate in the endometriosis group was 31.3% and that in the control group was 14.3%. The difference between two groups was also significant (P<0.01). When determining CA125 alone to diagnose endometriosis, the sensitivity rate was 58.3% and specificity rate was 87.5%. If determining EMAb alone to diagnose endometriosis, the sensitivity rate was 31.3% and specificity rate was 85.7%. When one of them was used as diagnostic criterion, the sensitivity and specificity were 64.6% and 73.2% respectively. If combining use of both CA125 and EMAb as diagnostic criterion, the sensitivity and specificity were 25.0% and 100% respectively.Conclusions The determination of serum CA125 or EMAb levels is helpful for the qualitative diagnosis of endometriosis, especially using them combined, the diagnostic accuracy may be enhanced.

Key words: endometrial antibody (EMAb), endometriosis, diagnosis