《中国康复理论与实践》

《中国康复理论与实践》 ›› 2003, Vol. 9 ›› Issue (05): 286-288.

• 基础研究 • 上一篇    下一篇

中药SSY-B2对隔海马穹窿伞切断致大鼠学习记忆障碍的改善作用

陆华宝1,2;李林1;安文林1;叶翠飞1;张丽1   

  1. 1.首都医科大学宣武医院 北京市 100035;2.北京博爱医院 北京市 100077
  • 收稿日期:2003-03-17 出版日期:2003-05-25 发布日期:2003-05-25

Effect of SSY-B2 on improvement of learning/memory function of rats with bilateral fornix/fimbria transection

LU Hua-bao,LI Lin,AN Wen-lin,et al   

  1. Beijing Xuanwu Hospital,Beijing 100035,China
  • Received:2003-03-17 Published:2003-05-25 Online:2003-05-25

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被引次数

49

摘要： 目的观察中药提取物SSY-B2对穹窿伞切断致大鼠学习记忆障碍的改善作用。方法成年雄性SD大鼠随机分为6组:假手术组、模型组、阳性对照药脑复康治疗组、SSY-B2小剂量治疗组(1.5g生药/kg),SSY-B2中剂量治疗组(3g生药/kg),SSY-B2大剂量治疗组(6g生药/kg)。术前0.5—1小时灌胃给予试验用药直到行为学测试结束。手术后第4周开始进行Morris水迷宫测试,记录游出时间;第6周进行通道式水迷宫测试记录游出时间和错误次数。结果小、中剂量SSY-B2治疗能缩短大鼠的游出时间或减少错误次数。结论SSY-B2具有改善穹窿伞切断所致的空间学习记忆障碍的作用。这种作用可能与中枢神经系统的功能代偿有关。

关键词: 中药, SSY-B2, 学习记忆障碍, 康复

Abstract: ObjectiveTo study the effect of SSY-B2 on improvement of learning/memory function of rats with bilateral fornix/fimbria transection.MethodsMale adult SD rats were divided randomly into 6 groups as sham group,model group,positive control agent piracetam group, SSY-B2 low(1.5g crude drug/kg), medium(3g crude drug/kg)and high dosage (6g crude drug/kg)group. Half to 1 hour before operation, water or drugs were fed introgastrically to each group respectively. From the fourth week, Morris water maze and tunnel water maze tests were used. Escape latency of rats in Morris test, escape latency and errors in tunnel test were recorded.ResultsIn both Morris test and tunnel water maze test, low dosage and medium of SSY-B2 markedly shorten the escape latency or reduced the errors.ConclusionsSSY-B2 can ameliorate spatial learning/memory dysfunction produced by fornix/fimbria transection. Functional compensation in other neural structure other than regeneration of the septohippocampal pathway is considered to be responsible for the effects.

Key words: traditional Chinese medicine, SSY-B2, learning/memory impairment, rehabilitation