《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (11): 1256-1259.

• 国际会议报道 • 上一篇    下一篇

急性脑梗死患者外周血清巨噬细胞移动抑制因子、基质金属蛋白酶-9和超敏C-反应蛋白水平与病情严重程度的关系

于治华，王君，樊建华，高红华，高连波
  

  1. 作者单位：中国医科大学附属第四医院神经内科，辽宁沈阳市 110032。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-11-25 发布日期:2015-11-25

Relationship of Serum Macrophage Migration Inhibitory Factor, Matrix Metalloproteinase-9 and Hypersensitive C-Reactive Protein with Severity of Acute Cerebral Infarction

YU Zhi-hua, WANG Jun, FAN Jian-hua, GAO Hong-hua, GAO Lian-bo
  

  1. Department of Neurology, the Fourth Hospital Affiliated to China Medical University, Shenyang, Liaoning 110032, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-11-25 Online:2015-11-25

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摘要： 目的 探讨急性脑梗死患者血清巨噬细胞移动抑制因子(MIF)、基质金属蛋白酶-9 (MMP-9)、超敏 C-反应蛋白(hs-CRP)水平与病情严重程度的相关性。方法 急性脑梗死患者101例根据美国国立卫生研究院卒中量表(NIHSS)评分分为轻型脑梗死组(A组，NIHSS评分<4分，n=38)、中型脑梗死组(B组，NIHSS评分 4~15分，n=36)和重型脑梗死组(C组，NIHSS评分>15分，n=27)；同期住院44例有动脉粥样硬化危险因素非急性脑梗死患者为对照组(D组)。酶联免疫吸附法测定血清中MIF、MMP-9水平，免疫散射比浊法检测 hs-CRP水平。结果 各组间 MIF、MMP-9及 hs-CRP水平从高到低依次为 C组、B组、A组、D组(P<0.05)。MIF与MMP-9 (r=0.301, P<0.01)和hs-CRP (r=0.309, P<0.001)呈正相关。结论 急性脑梗死患者血清MIF、MMP-9、hs-CRP水平升高，可能预测动脉粥样硬化斑块稳定性。

关键词: 急性脑梗死, 动脉粥样硬化, 巨噬细胞移动抑制因子, 基质金属蛋白酶-9, 超敏C-反应蛋白, 美国国立卫生研究院卒中量表

Abstract: Objective To investigate the relationship of serum levels of macrophage migration inhibitory factor (MIF), matrix metalloproteinase-9 (MMP-9), hypersensitive C-reactive protein (hs-CRP) with the severity of acute cerebral infarction (ACI). Methods 101 patients with ACI were envolved and divided into 3 groups according to the scores of National Institute of Health Stroke Scale (NIHSS): mild group (group A, n=38, NIHSS score<4), moderate group (group B, n=36, NIHSS score 4-15) and severe group (group C, n=27, NIHSS score>15). Meanwhile, 44 non-ACI inpatients with atherosclerosis were included as control group (group D). Their serum MIF and MMP-9 were detected with ELISA, and hs-CRP with immunoturbidimety. Results The levels of serum MIF, MMP-9 and hs-CRP ranged from more to less as groups C, B, A and D (P<0.05). There was positive correlation of MIF with MMP-9 (r=0.301, P<0.01) and hs-CRP (r=0.309, P< 0.001). Conclusion Serum MIF, MMP-9 and hs-CRP levels increased with the severity in ACI patients, which may be prediction of atherosclerotic plaque instability.

Key words: acute cerebral infarction, atherosclerosis, macrophage migration inhibitory factor, matrix metalloproteinase-9, hypersensitive C-reactive protein, National Institute of Health Stroke Scale