《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (10): 1187-1190.

• 基础研究 • 上一篇    下一篇

酒精性脑损伤的突触机制及其修复策略述评

徐德峰 1,2,3，赵谋明 1，马忠华 2，苏国万 1，张婷 2   

  1. 1. 华南理工大学轻工与食品学院，广东广州市 510640；2.无限极(中国)有限公司技术中心，广东广州市 510665；3.广东海洋大学食品科技学院，广东湛江市 524088。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-10-25 发布日期:2015-10-25

Synaptic Mechanism and Repairing Strategies for Alcoholic Recognition Impairment (review)

XU De-feng1,2,3, ZHAO Mou-ming1, MA Zhong-hua2, SU Guo-wan1, ZHANG Ting2   

  1. 1. College of Light Industry and Food Science Technology, South China University of Technology, Guangzhou, Guangdong 510640, China; 2. Technique Center of Infinitus (China) Co., Ltd., Guangzhou, Guangdong 510665, China; 3. College of Food Science and Technology of Guangdong Ocean University, Zhanjiang, Guangdong 524088, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-10-25 Online:2015-10-25

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摘要： 酒精性痴呆日益成为严峻的医学和社会问题，整体机制不明是目前酒精性脑损伤干预和治疗的瓶颈。突触作为神经元之间递质释放与跨膜信息传递及整合的核心结构，对于学习记忆等脑的高级功能具有决定性作用。本文基于突触传递的神经生物学基础，围绕酒精分子胁迫下突触传递过程和效率的变化，分别从突触形态结构、物质基础、信号转导等层面，系统评述了酒精性脑损伤的突触机制及其修复策略，以期为酒精性脑损伤的深入研究和益智类保健食品开发提供思路借鉴。

关键词: 酒精性脑损伤, 突触机制, 修复策略, 综述

Abstract: Alcoholic dementia is increasingly becoming both a severe medical issue and a social problem; the unknown overall mechanism is the bottleneck for effective intervention and treatment of alcoholic brain injury. As the primary structure for the release, transmission of neurotransmitter and information integration between neurons, synapse plays a significant role in performing the advanced function of brain, such as learning and memory. Based on the neurobiological principles of synaptic structure and function, the changes in process and efficiency of synaptic transmission and information integration stressed by alcoholic molecular were reviewed in comparison with the normal process. The molecular mechanisms for alcoholic brain damage in learning and memory abilities were systematically discussed from the levels of synaptic morphology, material components, and signal transduction, respectively, and the repairing strategies for the damaged synaptic structure were proposed accordingly. Hopefully, this review could provide a deep insight into understanding the molecular mechanism of alcoholic brain damage, and draw ideas for the memory-enhancing peptides development.

Key words: alcoholic brain injury, synaptic mechanism, repairing strategies, review