《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (09): 1045-1048.

• 基础研究 • 上一篇    下一篇

脊髓损伤生物标记物的研究进展

王玉明 1，唐丽 2，杨德刚 1，朱致敏 3   

  1. 王玉明(1965-)，男，汉族，内蒙古包头市人，硕士，副主任医师，主要研究方向：骨科和脊柱脊髓损伤。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-09-25 发布日期:2015-09-25

Advance in Research of Biomarkers of Spinal Cord Injury (review)

WANG Yu-ming1, TANG Li2, YANG De-gang1, ZHU Zhi-min3   

  1. 1. Department of Spinal and Neural Function Reconstruction, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China; 2. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China; 3. The Lianjiang People's Hospital, Lianjiang, Guangdong 524400, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-09-25 Online:2015-09-25

PDF (PC)

被引次数

7

摘要： 脊髓损伤后各病理阶段均有各种蛋白表达，代表损伤和修复的病理变化。发现并筛选出理想的生物标志物，有助于进一步评估复杂的脊髓损伤生物反应并判断预后。目前，已有部分研究就神经元特异性烯醇化酶(NSE)、星形胶质原性钙结合蛋白S-100β作为脊髓损伤的血清学标志物进行了初步探索。但是，其特异性和敏感性仍需进一步明确。未来仍需开发能预测功能结果的理想生物标志物。

关键词: 脊髓损伤, 生物标记物, 综述

Abstract: Various functional proteins are differently expressed in each pathologic stage after spinal cord injury, representing injury and the pathological change of repair. Ideal biomarker is helpful to evaluate complicated biological reactions of spinal cord injury and predict prognosis. As specific serum markers of central nerve injury, neuron-specific enolase (NSE) and astrocyte primary calcium binding protein S-100β had been studied preliminarily, but the specificity and sensitivity need more research. Future efforts still need to develop ideal biomarkers to predict functional outcome.

Key words: spinal cord injury, biomarker, review