《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (08): 953-956.

• 特稿 • 上一篇    下一篇

鲑鱼降钙素治疗脊髓损伤致骨质疏松症的效果

李军，杜良杰，刘宏炜，周天健，董学超，范维娇，郭韵，王冲，高峰，杨德刚，陈亮，杨明亮   

  1. 1.首都医科大学康复医学院，北京市100068；2.中国康复研究中心北京博爱医院脊柱脊髓神经功能重建科，北京市100068。作者简介：李军(1976-)，男，汉族，湖北荆州市人，硕士，主治医师，主要研究方向：脊柱脊髓与周围神经损伤。通讯作者：杜良杰。E-mail: strongneck@qq.com。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-08-25 发布日期:2015-08-25

Effect of Salmon Calcitonin on Osteoporosis Induced by Spinal Cord Injury

LI Jun, DU Liang-jie, LIU Hong-wei, ZHOU Tian-jian, DONG Xue-chao, FAN Wei-jiao, GUO Yun, WANG Chong, GAO Feng, YANG De-gang, CHEN Liang, YANG Ming-liang   

  1. 1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China; 2. Department of Spinal and Neural Function Reconstruction, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-08-25 Online:2015-08-25

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摘要： 目的观察鲑鱼降钙素治疗脊髓损伤所致骨质疏松症的临床效果。方法2011 年9 月~2014 年9 月本科收治的脊髓损伤致骨质疏松症患者100 例，按随机数字表法将其分为对照组(n=50)和观察组(n=50)。对照组在康复理疗的基础上单纯给予维生素D3，观察组则在康复理疗的基础上给予维生素D3联合鲑鱼降钙素治疗，共6 个月。测定治疗不同时间段患者疼痛视觉模拟评分(VAS)，腰椎及股骨颈骨密度(BMD)及甲状旁腺素(PTH)、骨钙素(BGP)、1,25-双羟维生素D3[1,25-(OH)2D3]等生化指标的变化情况。结果治疗1 个月、2 个月、3 个月及6 个月后观察组患者VAS评分显著低于对照组(P<0.001)。治疗后，观察组腰椎及股骨颈骨密度均显著高于对照组(P<0.001)；观察组PTH、BGP均显著低于对照组(P<0.001)，1,25-(OH)2D3显著高于对照组(P<0.001)。结论加用鲑鱼降钙素可有效减轻脊髓损伤所致骨质疏松症患者的骨性疼痛程度，提升患者骨密度。

关键词: 脊髓损伤, 骨质疏松, 维生素D3, 鲑鱼降钙素

Abstract: Objective To explore the effect of salmon calcitonin on osteoporosis induced by spinal cord injury. Methods 100 patients with osteoporosis induced by spinal cord injury from September 2011 to September 2014 in our department were included. They were randomly divided into control group (n=50) and observation group (n=50). The control group received vitamin D3 only, while the observation group received vitamin D3 combined with salmon calcitonin on the basis of rehabilitation physiotherapy, for 6 months. Visual Analogue Scale (VAS) of pain was evaluated in different periods. The bone mineral density (BMD) of lumbar spine and femoral neck, the parathyroid hormone (PTH), bone gla protein (BGP) and 1,25- dihydroxy vitamin D3 (1,25-(OH)2D3) were tested and recorded. Results The VAS score was lower in the observation group than in the control group 1, 2, 3 and 6 months after treatment (P<0.001). The BMD of lumbar spine and femoral neck was significantly higher, the PTH and BGP were significantly lower and the 1,25-(OH)2D3 was significantly higher in the observation group than in the control group after treatment (P<0.001). Conclusion Combination of salmon calcitonin can effectively reduce the bone pain and improve the BMD in patients with osteoporosis induced by spinal cord injury.

Key words: spinal cord injury, osteoporosis, vitamin D3, salmon calcitonin