《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (08): 929-933.

• 特稿 • 上一篇    下一篇

工作记忆训练对脑卒中患者大脑功能激活的影响

陈正威1，张璞2，恽晓平1,2   

  1. 1.首都医科大学康复医学院，北京市100068；2.中国康复研究中心北京博爱医院康复评定科，北京市100068。作者简介：陈正威(1990-)，男，汉族，江苏连云港市人，硕士研究生，主要研究方向：多模态磁共振技术对脑损伤后工作记忆损害康复的脑机制研究。通讯作者：恽晓平，女，硕士，主任医师，教授。E-mail: xiaoping_yun@163.com。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-08-25 发布日期:2015-08-25

Effects of Working Memory Training on Brain Functional Activition for Stroke Patients

CHEN Zheng-wei1, ZHANG Pu2, YUN Xiao-ping1,2   

  1. 1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China; 2. Department of Rehabilitation Evaluation, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-08-25 Online:2015-08-25

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摘要： 目的研究计算机化工作记忆训练对脑卒中患者工作记忆及大脑功能激活的影响。方法3 例脑卒中患者作为训练组，10 名健康成年被试作为正常对照组。训练组接受4 周工作记忆训练，对照组不接受任何训练。训练前及训练后各被试均接受认知心理行为测验和神经影像学测验(任务态fMRI)。结果工作记忆训练可有效提升脑卒中患者工作记忆、流体智力及注意力水平(P<0.001)；工作记忆训练可改善异常功能激活模式并使功能激活网络发生重组。结论工作记忆训练可作为有效的康复干预措施用于脑卒中患者的认知功能康复。

关键词: 脑卒中, 工作记忆训练, 功能磁共振成像, 功能激活, 流体智力, 注意力

Abstract: Objective To explore the effects of computerized working memory training on working memory and brain functional activition for stroke paitents. Methods 3 stroke patients voluntarily joined in the study, 10 healthy adults were recruited as control group. The patients received computerized working memory training for 4 weeks. Cognitive psychological tests (the n-back task, Stroop task and Raven`s Advanced Progressive Matrices task) and neuroimaging test (task- state functional magnetic resonance imaging) were administered before and after treatment. Results Working memory training significantly improved the working memory, fluid intelligence and attention for each trained patient (P<0.001), and could renovate the abnormal functional activity model and reorganize the functional brain network. Conclusion Computerized working memory could be used as an effective cognitive rehabilitation intervention for stroke patients.

Key words: stroke, working memory training, functional magnetic resonance imaging, functional activation, fluid intelligence, attention