《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (04): 432-435.

• 基础研究 • 上一篇    下一篇

肿瘤坏死因子-α和白细胞介素-6在侵袭性垂体瘤中的表达

吴建龙 1a，乔建勇 1b，段庆华 1a   

  1. 1.承德市中心医院，a.病理科；b.神经外科，河北承德市 067000。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-04-25 发布日期:2015-04-25

Expression of Tumor Necrosis Factor-α and Interleukin-6 in Invasive Pituitary Adenoma

WU Jian-long1a, QIAO Jian-yong1b, DUAN Qing-hua1a
   

  1. 1. a. Department of Pathology; b. Department of Neurosurgery, Chengde Central Hospital, Chengde, Hebei 067000, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-04-25 Online:2015-04-25

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摘要： 目的 研究肿瘤坏死因子-α (TNF-α)和白细胞介素-6 (IL-6)在侵袭性垂体瘤(IPA)中的表达。方法 采用免疫组织化学方法(SP法)检测40例IPA和40例非侵袭性垂体瘤(NIPA)组织中TNF-α和IL-6的表达。结果 TNF-α、IL-6在IPA组织中的表达均高于NIPA (P<0.05)。结论 TNF-α、IL-6可能在IPA的发生、发展过程发挥作用。

关键词: 侵袭性垂体瘤, 肿瘤坏死因子-α, 白细胞介素-6

Abstract: Objective To study the tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) expressed in invasive pituitary adenomas (IPA). Methods The expression of TNF-α and IL-6 were observed with immunohistochemstry (SP approach) in tissue from 40 cases of non-invasive pituitary adenomas (NIPA) and 40 cases of IPA. Results The expression of both TNF-α and IL-6 was significantly increased in the IPA tissues compared with those of NIPA (P<0.05). Conclusion TNF-α and IL-6 may play a role in the occurrence and development of IPA.

Key words: invasive pituitary adenoma, tumor necrosis factor-α, interleukin-6