《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (04): 378-381.

• 专题 • 上一篇    下一篇

脊髓损伤致脑部结构功能重塑的机制研究进展

冯东亮 1,2，张海鸿 2，伍亚民 1
   

  1. 1.第三军医大学大坪医院·野战外科研究所三室，创伤、烧伤与复合伤国家重点实验室，重庆市 400042；2.兰州大学第二临床医学院骨科，甘肃兰州市 730030。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-04-25 发布日期:2015-04-25

Advance in Mechanism of Brain Remodeling Induced by Spinal Cord Injury (review)

FENG Dong-liang1,2, ZHANG Hai-hong2, WU Ya-min1
   

  1. 1. Department 3 of Research Institute of Surgery, Daping Hospital, Third Military Medical University, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing 400042, China; 2. Department of Orthopedics, Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu 730030, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-04-25 Online:2015-04-25

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被引次数

2

摘要： 近几十年随着电生理学和神经影像学技术的发展，研究者发现脊髓损伤后不仅脊髓本身发生病理变化，还可引起脑内结构和功能改变。本文从脊髓损伤引起脑部神经细胞变性、脑内神经营养因子变化、脑内结构和功能重塑及其常用药物治疗的影响几个方面，综述脊髓损伤对脑内结构和功能重塑的影响和可能的机制。

关键词: 脊髓损伤, 脑损伤, 神经营养因子, 功能重塑, 综述

Abstract: In recent decades, with the development of electrophysiological and neuroimaging techniques, the researchers found that spinal cord injury (SCI) not only caused pathological changes in the spinal cord, but also in the brain. This paper reviewed the influence of SCI on the structure and function of the brain in terms of brain neuron degeneration caused by SCI, the changes of neurotrophic factor in brain, and the side-effects of medicine.

Key words: spinal cord injury, brain injury, neurotrophic factor, function remodeling, review