《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (03): 338-340.

• 临床研究 • 上一篇    下一篇

脑性瘫痪儿童的体液免疫水平

谢鸿翔1，林波1，刘合建2，刘楠1，邬刚燕1
   

  1. 1.宁波市康复医院儿童康复科，浙江宁波市315040；2.上海市第一人民医院康复医学科，上海市200080。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-03-25 发布日期:2015-03-25

Humoral Immune Function in Children with Cerebral Palsy

XIE Hong-xiang1, LIN Bo1, LIU He-jian2, LIU Nan1, WU Gang-yan1
   

  1. 1. Department of Children Rehabilitation, Ningbo Rehabilitation Hospital, Ningbo, Zhejiang 315040, China; 2. Department of Rehabilitation, Shanghai General Hospital, Shanghai 200080, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-03-25 Online:2015-03-25

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被引次数

4

摘要： 目的调查脑瘫患儿免疫功能水平。方法脑瘫患儿59 例，采用粗大运动功能分级系统(GMFCS)进行评估，检测患儿及非脑瘫儿童61 名(对照组)血清IgG、IgA、lgM，补体C3、C4水平。结果与对照组相比，脑瘫患儿血清免疫球蛋白(Ig)G、IgA、lgM，补体C3、C4水平显著降低(P<0.001)；不同GMFCS分级脑瘫患儿间，IgG、IgM、补体C4有显著性差异(P<0.05)，IgA、补体C3无显著性差异(P>0.05)。结论脑瘫患儿可能存在体液免疫功能异常，并可能与疾病严重程度有关，应引起注意。

关键词: 脑性瘫痪, 粗大运动功能, 免疫球蛋白, 补体

Abstract: Objective To investigate the levels of immunoglobulins and complement in children with cerebral palsy. Methods 59 children with cerebral palsy were assessed with Gross Motor Function Classification System (GMFCS), and the serum levels of immunoglobulin (Ig)G, IgA, lgM, complements C3 and C4 were measured in the children with cerebral palsy and other 61 children without cerebral palsy (controls). Results The serum levels of IgG, IgA, lgM, complement C3 and C4 decreased significantly in the children with cerebral palsy compared with the controls (P<0.001). There was significant difference in the levels of IgG, IgM, and complement C4 among cerebral palsy children of different grades of GMFCS (P<0.05), but not in the levels of IgA and complement C3 (P>0.05). Conclusion There is humoral immune dysfunction in some children with cerebral palsy, which may associated with the severity of the disease.

Key words: cerebral palsy, Gross Motor Function Classification System, immunoglobulin, complement