《中国康复理论与实践》

《中国康复理论与实践》 ›› 2015, Vol. 21 ›› Issue (01): 62-064.

• 综述 • 上一篇    下一篇

视黄醇结合蛋白4 与糖尿病血管病变的研究进展

李丹玲1，张景义2
   

  1. 1.河北联合大学建设路校区，河北唐山市063000；2.河北联合大学附属开滦总医院，河北唐山市063000。
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-01-25 发布日期:2015-01-25

Relationship between Retinol Binding Protein 4 and Diabetic Vascular Impairment (review)

LI Dan-ling, ZHANG Jing-yi.
  

  1. Jianshe Road Campus of Hebei United University, Tangshan, Hebei 063000, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-01-25 Online:2015-01-25

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被引次数

4

摘要： 视黄醇结合蛋白4(RBP4)是一种由肝脏合成、存在于血液循环中的脂肪细胞因子。它与糖尿病大血管并发症的发生密切相关，同时也可能促进了糖尿病微血管病变的发生和发展。本文概述RBP4 的结构和功能，及其与冠心病、动脉粥样硬化、糖尿病肾病、糖尿病视网膜病变关系的研究进展。

关键词: 视黄醇结合蛋白4, 糖尿病, 血管病变, 冠状动脉性心脏病, 动脉粥样硬化, 综述

Abstract: Retinol binding protein 4 (RBP4), synthesized in the liver, is an adipocytokine existing in the circulation. It is closely related to the incidence of macrovascular complications of diabetes. It also promotes the occurrence and development of diabetic microangiopathy. This paper summarized the progress in the field about the structure and function of RBP4, RBP4 and coronary heart disease and atherosclerosis, as well as RBP4 and diabetic nephropathy and diabetic retinopathy.

Key words: retinol binding protein 4, diabetes mellitus, vascular disease, coronary heart disease, atheroselerosis, review