《中国康复理论与实践》

《中国康复理论与实践》 ›› 2014, Vol. 20 ›› Issue (11): 1031-1034.

• 综述 • 上一篇    下一篇

tau 蛋白与阿尔茨海默病的研究进展

胡江平，耿瑞，李凯军   

  1. 牡丹江医学院，黑龙江牡丹江市157011
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-11-25 发布日期:2014-11-25

Advance in Relationship between Tau Protein and Alzheimer's Disease (review)

HU Jiang-ping, GENG Rui, LI Kai-jun   

  1. Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-11-25 Online:2014-11-25

PDF (PC)

被引次数

14

摘要： 阿尔茨海默病(AD)的主要病理变化之一是神经元内出现以磷酸化tau 蛋白为主要成分的神经原纤维缠结。以往研究主要集中在老年斑及Aβ层面，近年来的研究表明，tau 蛋白与AD的发生发展有着密切联系，tau 蛋白异常磷酸化已成为目前的研究点。本文从蛋白激酶及磷酸酶角度对tau蛋白磷酸化与AD之间的关系进行综述。

关键词: 阿尔茨海默病, tau蛋白, 磷酸化, 神经原纤维缠结, 综述

Abstract: Alzheimer's disease is a common neurodegenerative disease. One of the main pathology is neurofibrillary tangles in neurons,in which principal component is the phosphorylation of tau protein. Previous studies focused on senile plaques and Aβ levels. Recent studies indicated that the development of tau protein closely associated with Alzheimer's disease, especially the abnormal phosphorylation. This paper reviewed the relationship between tau protein phosphorylation and Alzheimer's disease based on the perspective of protein kinases and phosphatases.

Key words: Alzheime r's disease, tau protein, phosphorylation, neurofibrillary tangles, review