《中国康复理论与实践》

《中国康复理论与实践》 ›› 2014, Vol. 20 ›› Issue (3): 250-252.

• 论文 • 上一篇    下一篇

骨保护素/核因子-κB受体活化因子配体/核因子-κB受体活化因子信号通路与骨质疏松的研究进展

李盛村，鲍捷，王静，王国祥   

  1. 苏州大学体育学院，江苏苏州市215021。
  • 收稿日期:2013-09-02 修回日期:2013-11-01 出版日期:2014-03-25 发布日期:2014-03-25
  • 通讯作者: 王国祥

Stress Sensitive Signal Pathway Osteoprotegerin/Receptor Activator of Nuclear Factor-κB ligand/Receptor Activator of Nuclear Factor-κB and Osteoporosis (review)

LI Sheng-cun, BAO Jie, WANG Jing, et al.   

  1. School of Physical Education of Soochow University, Suzhou 215021, Jiangsu, China
  • Received:2013-09-02 Revised:2013-11-01 Published:2014-03-25 Online:2014-03-25

PDF (PC)

被引次数

10

摘要： 运动对骨质疏松症有积极作用，但其治疗的分子生物学机制仍未清楚。骨保护素/核因子-κB受体活化因子配体/核因子-κB受体活化因子(OPG/RANKL/RANK)信号通路的发现，有助于骨质疏松症的治疗。机械应力可以调节OPG/RANKL/RANK信号通路，参与预防和治疗骨质疏松进程。本文就应力敏感信号通路OPG/RANKL/RANK与骨质疏松的关系进行综述。

关键词: 骨质疏松症, 应力, 骨保护素, 核因子-κB受体活化因子配体, 核因子-κB受体活化因子, 信号通路, 综述

Abstract: Exercise is benefic for osteoporosis, without clear molecular biology mechanism. The osteoprotegerin/receptor activator of nuclear factor-κB ligand/receptor activator of nuclear factor-κB (OPG/RANKL/RANK) signal pathway contributes to osteoporosis, which can be mediated by mechanical force. Research progress on osteoporosis and the stress sensitive signal pathway OPG/RANKL/RANK were reviewed in this paper.

Key words: osteoporosis, stress, osteoprotegerin, receptor activator of nuclear factor-κB ligand, receptor activator of nuclear factor-κB, signal pathway, review