《中国康复理论与实践》

《中国康复理论与实践》 ›› 2014, Vol. 20 ›› Issue (3): 240-244.

• 论文 • 上一篇    下一篇

以微管相关蛋白Tau为靶点的抗阿尔茨海默病药物研究进展

郐学先，于建春，张兰   

  1. 1.天津中医药大学，天津市300193；2.天津中医药大学第一附属医院分子生物学实验室，天津市300193；3.首都医科大学宣武医院药物研究室，神经变性病教育部重点实验室，北京市100053。
  • 收稿日期:2013-08-23 修回日期:2013-08-30 出版日期:2014-03-25 发布日期:2014-03-25
  • 通讯作者: 张兰

Advance in Drug Development for Alzheimer's Disease Targeted Microtuble Associated Protein Tau (review)

KUAI Xue-xian, YU Jian-chun, ZHANG Lan.   

  1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • Received:2013-08-23 Revised:2013-08-30 Published:2014-03-25 Online:2014-03-25

PDF (PC)

被引次数

5

摘要： 阿尔茨海默病(AD)是老年人最常见的神经退行性疾病。微管相关蛋白tau 的改变与AD发病和进展密切相关。以tau 蛋白为靶标进行AD防治药物研究已成为近年AD研究领域的一大热点，主要包括抑制tau 蛋白磷酸化、聚集，加速tau 蛋白解聚。本文对以tau蛋白为靶标的AD防治药物研究的现状进行综述。

关键词: 阿尔茨海默病, 神经纤维缠结, 微管相关蛋白tau, 药物, 综述

Abstract: Alzheimer's disease (AD) is the general neurodegenerative disease in the elderly. Alterations of microtubule associated protein tau are closely related to the onset and progression of AD. The role of tau protein in the development of AD has been a focus in the current study of AD, with an emphasis on the identification of compounds that inhibit tau protein phosphorylation and aggregate, and accelerate tau protein depolymerization. The current research status of tau protein as target of AD preventive and therapeutic drug was also reviewed.

Key words: Alzheimer's disease, neurofibrillary tangles, microtubule associated protein tau, drug, review