《中国康复理论与实践》

《中国康复理论与实践》 ›› 2013, Vol. 19 ›› Issue (12): 1155-1158.

• 论文 • 上一篇    下一篇

成人部分性癫痫患者睡眠障碍特征分析

李晓裔，邵西仓，吴云，刘姝，李想，李玉琢   

  1. 贵州省人民医院神经电生理中心，贵州贵阳市550002。
  • 收稿日期:2013-04-07 修回日期:2013-06-12 出版日期:2013-12-25 发布日期:2013-12-25

Analysis of Sleep Characteristics of Adult Partial Epilepsy Patients

LI Xiao-yi, SHAO Xi-cang, WU Yun, et al.   

  1. Neuroelectrophysiological Center, Guizhou Provincial Pepole's Hospital, Guiyang 550002, Guizhou, China
  • Received:2013-04-07 Revised:2013-06-12 Published:2013-12-25 Online:2013-12-25

被引次数

22

摘要： 目的探讨成人部分性癫痫患者的睡眠特征。方法对初诊断的45 例成人部分性癫痫患者(患者组)和40 名健康者(对照组)行睡眠脑电图监测，分析其睡眠参数。用Epworth 嗜睡量表(ESS)行白天嗜睡状况评价。比较两组睡眠参数和ESS 评分的差异，并分析它们之间的关系。结果患者组ESS评分高于对照组(P<0.05)；与对照组相比，患者组总睡眠时间减少(P<0.05)，睡眠效率下降(P<0.05)，非快速眼动睡眠(NREM) 1、2 期及清醒期占总睡眠时间百分比增加(P<0.05)，NREM慢波睡眠期(3+4 期)占总睡眠时间百分比下降(P<0.05)；两组总记录时间、睡眠潜伏期、快速眼动睡眠(REM)潜伏期和觉醒次数无显著性差异(P>0.05)。患者组中，每月发作≥3 次者ESS 评分明显高于每月发作<3 次者(P<0.01)；与每月发作<3 次者比较，每月发作≥3 次者总睡眠时间减少(P<0.05)，睡眠效率下降(P<0.05)，NREM 1、2 期及清醒期占总睡眠时间的百分比增加(P<0.05)，NREM 3+4 期占总睡眠时间百分比下降(P<0.05)，REM期占总睡眠时间百分比下降(P<0.05)；两组间总记录时间、睡眠潜伏期、REM潜伏期和觉醒次数均无显著性差异(P>0.05)。患者组的ESS 评分与睡眠效率(r=-0.49, P<0.05)、NREM 3+4 期占总睡眠时间百分比(r=-0.54, P<0.05)呈负相关，与记录的其余睡眠参数不相关(P>0.05)。结论成年部分性癫痫患者有睡眠结构异常，白天嗜睡程度增高；癫痫发作可加重睡眠结构异常和白天嗜睡程度；睡眠参数异常与ESS评分有一定的相关性。

关键词: 成人部分性癫痫, Epworth嗜睡量表, 睡眠脑电图

Abstract: Objective To explore the sleep characteristics of adult partial epilepsy patients. Methods 45 patients newly diagnosed as adult partial epilepsy and 40 cases of healthy controls were monitored with sleep encephalogram (EEG), the sleep parameters were analyzed.Epworth Sleepiness Scale (ESS) was used to evaluate the daytime sleepiness next day. The sleep parameters and ESS score were compared between 2 groups, and the correlation between sleep parameters and ESS score in the patients were analyzed. Results The ESS score was higher in the patients than in the controls (P<0.05); Compared with the controls, the total sleep time decreased (P<0.05), the sleep efficiency reduced (P<0.05), the percentage of non-rapid eye movement sleep (NREM) stages 1 and 2 and the wakefulness stage increased (P<0.05), the percentage of NREM stages 3 and 4 decreased (P<0.05) in the patients; There was no significant difference in total recording time, sleep latency, REM latency, and arousal times between the patients and the controls (P>0.05). The ESS score was higher in the patients who attacked 3 times a month or more (group A) than less than 3 (group B). Compared with group B, the total sleep time decreased (P<0.05), the sleep efficiency reduced (P<0.05), the percentage of NREM stages 1 and 2 and the wakefulness stage increased (P<0.05), the percentage of NREM stages 3 and 4, and REM decreased (P<0.05) in group A. There was no significant difference in sleep latency, REM latency and arousal times between 2 groups (P>0.05). The ESS score of the patients was negatively correlated with sleep efficiency (r=-0.49, P<0.05) and the percentage of NREM stages 3 and 4 (r=-0.54, P<0.05), and was not correlated with other sleep parameters (P>0.05). Conclusion The sleep architecture of patients with adult partial epilepsy is abnormal, and their daytime sleepiness is more than healthy persons. Epileptic seizure can aggravate sleep architecture abnormality and daytime sleepiness. Abnormal sleep parameters are related with ESS score.

Key words: adult partial epilepsy, Epworth Sleepiness Score, sleep encephalogram