《中国康复理论与实践》

《中国康复理论与实践》 ›› 2013, Vol. 19 ›› Issue (09): 878-880.

• 论文 • 上一篇    下一篇

凝血因子ⅦR353Q基因多态性与中国汉族儿童脑性瘫痪的相关性研究

李晓捷，徐磊，康贝贝   

  1. 1.佳木斯大学康复医学院，黑龙江佳木斯市154002；2.佳木斯大学儿童神经康复实验室，黑龙江佳木斯市154002。
  • 收稿日期:2013-04-26 修回日期:2013-05-27 出版日期:2013-09-25 发布日期:2013-09-25

Relationship between Gene Polymorphism of Factor VII R353Q and Cerebral Palsy for Han Chinese Children

LI Xiao-jie, XU Lei,KANG Bei-bei.   

  1. Rehabilitation Medicine College of Jiamusi University, Children Neural Rehabilitation laboratory of Jiamusi University, Jiamusi 154002, Heilongjiang, China
  • Received:2013-04-26 Revised:2013-05-27 Published:2013-09-25 Online:2013-09-25

PDF (PC)

被引次数

6

摘要： 目的探讨凝血因子ⅦR353Q基因多态性与中国汉族儿童脑瘫的关系。方法应用聚合酶链反应与限制性片断长度多态性分析方法对160 例脑瘫患儿和137 名正常儿童的凝血因子ⅦR353Q基因型和等位基因进行测定。结果脑瘫组和对照组人群凝血因子ⅦR353Q基因型分布符合Hardy-weinberg 平衡定律(P>0.05)，两组凝血因子ⅦR353Q基因型(P=0.436)和等位基因分布无显著性差异(P=0.182)。结论凝血因子ⅦR353Q基因多态性不是中国汉族儿童脑瘫发病的遗传易感因子。

关键词: 脑性瘫痪, 汉族, 凝血因子ⅦR353Q, 基因多态性

Abstract: Objective To investigate the relationship between gene polymorphism of factor VII R353Q (FVII R353Q) and cerebral palsy for Han Chinese children. Methods Polymerase chain reaction-restricted fragment length polymorphism were used to determine genotype and allele of R353Q gene in 160 children with cerebral palsy and 137 normal children. Results The genotype of FVII R353Q is close to Hardy-Weinberg equilibrium in both CP group and control group (P>0.05). There was not significant difference in the distribution of the allelic frequency and genotype of FVII R353Q between the both groups (P=0.436, P=0.182, respectively). Conclusion The gene polymorphism of FVII R353Q is not significantly related with cerebral palsy for Han Chinese children.

Key words: cerebral palsy, Han, factor VII R353Q, gene polymorphism